Advancing Basic and Translational Science: Highlights From the Basic Science Workshop at the GRAPPA 2023 Annual Meeting.

IF 3.6 2区 医学 Q2 RHEUMATOLOGY
M Elaine Husni, Chris Sun, Unnikrishnan M Chandrasekharan, Samuel T Hwang
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引用次数: 0

Abstract

Contemporary translational and clinical research advances in psoriatic disease (PsD) were highlighted at the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2023 annual meeting basic science workshop. This year's workshop focused on key topics, including the significance of the annual GRAPPA meetings as a platform for collaboration and knowledge exchange. Discussions centered around expanding our understanding of tumor necrosis factor inhibitor (TNFi) treatment in PsD and enhancing early detection strategies for PsD comorbidities, specifically for the timely intervention and management of cardiovascular (CV) comorbidities. Insights on the role of the C-C chemokine receptor type 6 (CCR6) in PsD and psoriatic arthritis were provided, suggesting that blockade of CCR6 can reduce psoriasis-like dermatitis and joint inflammation in mouse models.

推进基础科学和转化科学:GRAPPA 2023 年年会基础科学研讨会花絮。
银屑病和银屑病关节炎研究与评估组织(GRAPPA)2023年年会基础科学研讨会重点讨论了银屑病(PsD)的当代转化和临床研究进展。今年的研讨会重点讨论了一些关键议题,包括 GRAPPA 年会作为合作与知识交流平台的意义。讨论围绕扩大我们对肿瘤坏死因子抑制剂(TNFi)治疗 PsD 的认识以及加强 PsD 并发症的早期检测策略展开,特别是对心血管 (CV) 并发症的及时干预和管理。该研究对C-C趋化因子受体6型(CCR6)在银屑病和银屑病关节炎中的作用进行了深入研究,表明在小鼠模型中阻断CCR6可减轻银屑病样皮炎和关节炎症。
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来源期刊
Journal of Rheumatology
Journal of Rheumatology 医学-风湿病学
CiteScore
6.50
自引率
5.10%
发文量
285
审稿时长
1 months
期刊介绍: The Journal of Rheumatology is a monthly international serial edited by Earl D. Silverman. The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 41 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.
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