Advances in Psoriatic Disease Research: Insights From GRAPPA Pilot Research Awardees.

IF 3.6 2区医学 Q2 RHEUMATOLOGY

Journal of Rheumatology Pub Date : 2024-10-01 DOI:10.3899/jrheum.2024-0292

Ashley Elliott, Tejpal Gill, Jaehwan Kim, Maria S Shutova, Oliver FitzGerald, Stephen R Pennington, Madeleine Rooney, Atul Deodhar, Siba P Raychaudhuri, Wolf-Henning Boehncke, Kurt de Vlam, Vinod Chandran, Wilson Liao

引用次数: 0

Abstract

Research progress from the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) pilot award program was presented and discussed at the GRAPPA 2023 annual meeting. Topics included identification of protein biomarkers associated with enthesitis in psoriatic arthritis (PsA), the role of HLA-B27 on gut microbial dysbiosis in PsA, single-cell profiling of synovial fluid vs psoriatic skin lesions in PsA, and the role of mechanotransduction in hyperactivation of transforming growth factor-β via αVβ6 integrin in psoriatic epidermis.

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银屑病研究进展：GRAPPA 试点研究获奖者的见解。

银屑病和银屑病关节炎研究与评估小组（GRAPPA）试点奖励计划的研究进展在 GRAPPA 2023 年年会上进行了介绍和讨论。会议主题包括银屑病关节炎（PsA）中与关节炎相关的蛋白质生物标志物的鉴定、HLA-B27 在银屑病关节炎肠道微生物菌群失调中的作用、银屑病关节炎滑液与银屑病皮损的单细胞图谱分析，以及机械传导在通过银屑病表皮中的αVβ6整合素过度激活转化生长因子-β中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Rheumatology 医学-风湿病学

CiteScore

6.50

自引率

5.10%

发文量

285

审稿时长

1 months

期刊介绍： The Journal of Rheumatology is a monthly international serial edited by Earl D. Silverman. The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 41 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.