Prevalence of cognitive impairment (CI) in patients with multiple sclerosis (MS): A systematic review and meta-analysis.

Pub Date : 2024-01-01 DOI:10.22088/cjim.15.3.392

Mozhde Askari, Omid Mirmosayyeb, Fatemeh Fattahi, Hamed Ghoshouni, Elham Moases Ghaffary, Vahid Shaygannejad, Mahsa Ghajarzadeh

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引用次数: 0

Abstract

Background: One of the complications of multiple sclerosis (MS) is cognitive impairment (CI). The prevalence of CI is reported variously in previous studies. The goal of this systematic review and meta-analysis to estimate pooled prevalence of CI in patients with MS and also the prevalence of CI based on the type of applied test.

Methods: Two independent researchers systematically searched PubMed, Scopus, EMBASE, Web of Science, and google scholar as well as gray literature (conference abstracts, references of the references) which were published before up January 2022.

Results: We found 4089 articles by literature search, after deleting duplicates 3174 remained. Ninety articles remained for meta-analysis. The pooled prevalence of CI using all types of tests was 41% (95% CI: 38-44%) (I2=91.7%, p<0.001). The pooled prevalence of CI using BRB test was 39% (95%CI: 36-42%) (I2=89%, p<0.001). The pooled prevalence of CI using BICAMS was 44% (95%CI: 37-51%, I2=95.4%, p<0.001). The pooled prevalence of CI using MACFIMS was 44% (95% CI: 36-53%) (I2=89.3%, p<0.001).

Conclusions: The pooled prevalence of cognitive impairment in patients with MS is estimated as 41%, so CI it should be considered by clinicians.

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多发性硬化症（MS）患者认知障碍（CI）的患病率：系统回顾和荟萃分析。

背景：多发性硬化症（MS）的并发症之一是认知障碍（CI）：多发性硬化症（MS）的并发症之一是认知障碍（CI）。以往的研究对 CI 的患病率有不同的报道。本系统综述和荟萃分析的目的是估算多发性硬化症患者中 CI 的总体患病率，以及基于应用测试类型的 CI 患病率：两位独立研究人员系统检索了PubMed、Scopus、EMBASE、Web of Science和google scholar以及2022年1月之前发表的灰色文献（会议摘要、参考文献的参考文献）：我们通过文献检索找到了 4089 篇文章，删除重复文章后，还剩下 3174 篇。剩下 90 篇文章用于荟萃分析。使用所有类型的测试，CI 的汇总患病率为 41% (95% CI: 38-44%)（I2=91.7%，pConclusions）：据估计，多发性硬化症患者认知功能障碍的总患病率为 41%，因此临床医生应考虑认知功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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