Is Salivary Α-Amylase a Reliable Indicator of Psychological Status and Quality of Life in Patients with Oral Lichen Planus: a Case-Control Study.

IF 2.5 Q3 CELL BIOLOGY

Cellular Physiology and Biochemistry Pub Date : 2024-07-12 DOI:10.33594/000000714

Ana Glavina, Antonija Zoranić, Antonija Tadin, Livia Cigić, Daniela Šupe-Domić, Liborija Lugović-Mihić

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引用次数: 0

Abstract

Background/aims: The objectives of our study were to determine salivary α-amylase activity (stress biomarker) and its association with psychological status and quality of life (QoL), disease duration and intensity of symptoms (pain/burning) in patients with OLP.

Methods: A total of 50 subjects participated in this case-control study: 30 patients with oral lichen planus (OLP); 20 control subjects. Unstimulated whole saliva (UWS) was collected between 9 and 10 am to avoid diurnal fluctuations. Psychological status was assessed using the Croatian validated version of the original Depression, Anxiety and Stress Scale (DASS-21). The impact of oral health on QoL was assessed using the Croatian version of the Oral Health Impact Profile Questionnaire (OHIP-CRO14).

Results: There was no statistically significant difference in salivary α-amylase activity between patients with OLP (N=30) and control subjects (N=20) (133813.3 vs. 166815.5 U/L, p=0.314; t-test). Depression, anxiety and stress showed no statistically significant difference between patients with OLP and control subjects (p=0.076, p=0.111, p=0.209; t-test). The patients with OLP had statistically significantly poorer QoL (total) compared to control subjects (p=0.004, t-test). There was a moderate positive correlation between symptom intensity (pain/burning) and poor QoL (total) (r=0.584, p<0.001), the OHIP-CRO14 dimension "physical pain" (r=0.661, p<0.001), "psychological impossibility" (r=0.555, p<0.01), "handicap" (r=0.546, p<0.01).

Conclusion: Although salivary α-amylase showed no statistically significant difference between patients with OLP and control subjects, the patients with OLP had poorer psychological status (three times higher scores for depression and two times higher scores for anxiety) and poorer QoL compared to the control subjects. Recognising and treating mental disorders in patients with OLP is important in order to break the "vicious circle" and achieve a better QoL in these patients.

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唾液Α-淀粉酶是否是口腔扁平苔藓患者心理状态和生活质量的可靠指标：一项病例对照研究。

背景/目的我们的研究旨在确定唾液α-淀粉酶活性（应激生物标志物）及其与OLP患者的心理状态和生活质量（QoL）、病程和症状强度（疼痛/烧灼感）的关系：共有 50 名受试者参与了这项病例对照研究：方法：共有50名受试者参加了这项病例对照研究：30名口腔扁平苔藓（OLP）患者；20名对照组受试者。为避免昼夜波动，研究人员在上午 9 点至 10 点之间采集未受刺激的全唾液（UWS）。心理状况采用克罗地亚验证版抑郁、焦虑和压力量表（DASS-21）进行评估。口腔健康对生活质量的影响采用克罗地亚版口腔健康影响档案问卷（OHIP-CRO14）进行评估：结果：OLP患者（30人）与对照组（20人）的唾液α-淀粉酶活性差异无统计学意义（133813.3 U/L对166815.5 U/L，P=0.314；t检验）。在抑郁、焦虑和压力方面，OLP 患者与对照组之间的差异无统计学意义（P=0.076、P=0.111、P=0.209；t 检验）。与对照组相比，OLP 患者的生活质量（总）明显较差（p=0.004，t 检验）。症状强度（疼痛/烧灼感）与不良 QoL（总值）之间呈中度正相关（r=0.584，p）：虽然唾液α-淀粉酶在OLP患者和对照组之间没有统计学意义上的显著差异，但与对照组相比，OLP患者的心理状态更差（抑郁得分高出三倍，焦虑得分高出两倍），QoL也更差。要打破 "恶性循环"，提高患者的生活质量，就必须认识并治疗骨质疏松症患者的精神障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular Physiology and Biochemistry 生物-生理学

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Cellular Physiology and Biochemistry is a multidisciplinary scientific forum dedicated to advancing the frontiers of basic cellular research. It addresses scientists from both the physiological and biochemical disciplines as well as related fields such as genetics, molecular biology, pathophysiology, pathobiochemistry and cellular toxicology & pharmacology. Original papers and reviews on the mechanisms of intracellular transmission, cellular metabolism, cell growth, differentiation and death, ion channels and carriers, and the maintenance, regulation and disturbances of cell volume are presented. Appearing monthly under peer review, Cellular Physiology and Biochemistry takes an active role in the concerted international effort to unravel the mechanisms of cellular function.