The immunology of systemic lupus erythematosus

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-07-15 DOI:10.1038/s41590-024-01898-7

George C. Tsokos

引用次数: 0

Abstract

Understanding the pathogenesis and clinical manifestations of systemic lupus erythematosus (SLE) has been a great challenge. Reductionist approaches to understand the nature of the disease have identified many pathogenetic contributors that parallel clinical heterogeneity. This Review outlines the immunological control of SLE and looks to experimental tools and approaches that are improving our understanding of the complex contribution of interacting genetics, environment, sex and immunoregulatory factors and their interface with processes inherent to tissue parenchymal cells. Efforts to advance precision medicine in the care of patients with SLE along with treatment strategies to correct the immune system hold hope and are also examined. In this Review, the author outlines the complex immunology of systemic lupus erythematosus and how to treat it.

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系统性红斑狼疮的免疫学

了解系统性红斑狼疮（SLE）的发病机制和临床表现一直是一项巨大的挑战。通过还原论的方法来了解疾病的本质，发现了许多与临床异质性平行的致病因素。本综述概述了系统性红斑狼疮的免疫学控制，并展望了实验工具和方法，这些工具和方法正在提高我们对遗传学、环境、性别和免疫调节因子相互作用的复杂贡献及其与组织实质细胞固有过程的相互作用的认识。此外，该书还探讨了在系统性红斑狼疮患者护理中推进精准医疗的努力，以及纠正免疫系统的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.