Factors affecting age at menopause and their relationship with ovarian reserve: a comprehensive review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 Epub Date: 2024-07-15 DOI:10.1080/13625187.2024.2375281

Antonio La Marca, Marialaura Diamanti

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引用次数: 0

Abstract

Objective: The aim of this article was to discuss all the factors affecting the age at menopause and their correlation with ovarian reserve.

Materials and methods: A narrative review of original articles was performed using PubMed until December 2023. The following keywords were used to generate the list of citations: 'menopause', 'ovarian reserve' 'oocytes quality and quantity', 'ovarian ageing'.

Results: Menopause is the final step in the process of ovarian ageing and is influenced by the oocyte pool at birth. Conditions that accelerate follicle depletion during the reproductive lifespan lead to premature ovarian insufficiency (POI) and premature ovarian failure (POF), while a higher ovarian reserve is associated with a delayed time to menopause. Reproductive history, sociodemographic, lifestyle and iatrogenic factors may impact ovarian reserve and the age at menopause.

Conclusions: Some factors affecting the age at menopause are modifiable and the risks of early menopause may be preventable. We hypothesise that by addressing these modifiable factors we may also preserve ovarian reserve. However, further interventional studies are needed to evaluate the effects of the described strategies on ovarian reserve.

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影响绝经年龄的因素及其与卵巢储备功能的关系：全面综述。

目的：本文旨在讨论影响绝经年龄的所有因素及其与卵巢储备功能的相关性：本文旨在讨论影响绝经年龄的所有因素及其与卵巢储备功能的相关性：使用 PubMed 对截至 2023 年 12 月的原始文章进行了叙述性综述。以下关键词用于生成引文列表：更年期"、"卵巢储备"、"卵母细胞质量和数量"、"卵巢衰老"：更年期是卵巢衰老过程的最后一步，受出生时卵母细胞库的影响。在生育期内加速卵泡耗竭的情况会导致卵巢早衰（POI）和卵巢早衰（POF），而较高的卵巢储备与绝经时间推迟有关。生育史、社会人口、生活方式和先天性因素可能会影响卵巢储备和绝经年龄：结论：影响绝经年龄的一些因素是可以改变的，更年期提前的风险可能是可以预防的。我们假设，通过解决这些可改变的因素，我们也可以保护卵巢储备功能。然而，还需要进一步的干预研究来评估上述策略对卵巢储备功能的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.