[The expression and prognosis prediction of CFL-1 in head and neck squamous cell carcinoma].

Q4 Medicine

上海口腔医学 Pub Date : 2024-04-01

Kai Zhao, Yu-Ning Zhang, Shuai-Qi Ji, Ying Liu, Han Jiang

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引用次数: 0

Abstract

Purpose: The purpose of this study was to explore the expression, prognostic value and immune correlation of Cofilin 1 protein(CFL-1) in head and neck squamous cell carcinoma(HNSCC).

Methods: The expression and prognostic value of CFL-1 in head and neck squamous cell carcinoma(HNSCC) was explored in the cancer genome map database (TCGA) and gene expression total databases (GEO), and the potential immune pathway of CFL-1 in HNSCC was revealed by GESA and cibersoft analysis. The data were statistically analyzed using SPSS 26.0 software package.

Results: CFL-1 was significantly up-regulated in HNSCC tissue. The expression level of CFL-1 was significantly correlated with the overall survival status of HNSCC. High expression of CFL-1 was significantly associated with a lower overall survival rate. In addition, multivariate Cox survival analysis showed that CFL-1 expression was independent predictors of poor prognosis of HNSCC. GESA and cibersoft analysis showed that the imbalance of CFL-1 expression affected multiple signal pathways and infiltration of immune cells.

Conclusions: CFL-1 is highly expressed in HNSCC and is significantly associated with poor prognosis of NHSCC. It is a potential prognostic marker of HNSCC.

本刊更多论文

[CFL-1在头颈部鳞状细胞癌中的表达及预后预测]。

目的：本研究旨在探讨Cofilin 1蛋白（CFL-1）在头颈部鳞状细胞癌（HNSCC）中的表达、预后价值及免疫相关性：在癌症基因组图谱数据库（TCGA）和基因表达总数据库（GEO）中探讨了CFL-1在头颈部鳞癌（HNSCC）中的表达和预后价值，并通过GESA和cibersoft分析揭示了CFL-1在HNSCC中的潜在免疫通路。数据采用SPSS 26.0软件包进行统计分析：结果：CFL-1在HNSCC组织中明显上调。CFL-1的表达水平与HNSCC的总生存状况明显相关。CFL-1的高表达与较低的总生存率明显相关。此外，多变量 Cox 生存分析表明，CFL-1 的表达是 HNSCC 不良预后的独立预测因子。GESA和cibersoft分析表明，CFL-1表达的不平衡影响了多种信号通路和免疫细胞的浸润：结论：CFL-1在HNSCC中高表达，与NHSCC的不良预后显著相关。结论：CFL-1在HNSCC中高表达，与NHSCC的不良预后明显相关，是HNSCC潜在的预后标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

上海口腔医学 Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

5299

期刊介绍： "Shanghai Journal of Stomatology (SJS)" is a comprehensive academic journal of stomatology directed by Shanghai Jiao Tong University and sponsored by the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. The main columns include basic research, clinical research, column articles, clinical summaries, reviews, academic lectures, etc., which are suitable for reference by clinicians, scientific researchers and teaching personnel at all levels engaged in oral medicine.