Long-term Follow-up Results of Idiopathic Epiretinal Membrane Removal in the Eyes with Ectopic Inner Foveal Retinal Layers.

IF 0.5 Q4 OPHTHALMOLOGY

Middle East African Journal of Ophthalmology Pub Date : 2024-06-14 eCollection Date: 2023-04-01 DOI:10.4103/meajo.meajo_51_24

Ecem O Tokuc, Levent Karabas, Ilkay K Muftuoglu, Sevim A Seyyar

{"title":"Long-term Follow-up Results of Idiopathic Epiretinal Membrane Removal in the Eyes with Ectopic Inner Foveal Retinal Layers.","authors":"Ecem O Tokuc, Levent Karabas, Ilkay K Muftuoglu, Sevim A Seyyar","doi":"10.4103/meajo.meajo_51_24","DOIUrl":null,"url":null,"abstract":"Purpose: The purpose of this study was to evaluate pre- and perioperative factors related to time for the evolution of ectopic inner foveal layers (EIFL) following pars plana vitrectomy (PPV) for epiretinal membrane (ERM) peeling.Methods: This retrospective study included 81 consecutive eyes with idiopathic ERM that underwent vitrectomy surgery. Standard PPV + internal limiting membrane peeling was performed in all cases. A comprehensive ophthalmic examination was performed for all patients before and 1, 3, 6, and 12 months, and the last follow-up after surgery. We observed the postoperative improvement in EIFL severity in the short-term and longest follow-up and evaluated anatomical and functional improvement. Several parameters were assessed using the multivariate COX proportional hazard analysis.Results: Eighty patients (81 eyes) with a mean age of 70.33 ± 7.75 years were followed for a mean of 34.37 ± 23.61 months, and 55.5% of eyes (45 eyes) with EIFL ERM showed improvement of foveal contour to a better stage at the last follow-up. The median estimated time for evolving to a better stage was 29.73 months for stage 2, 49.68 months for stage 3, and 38.67 months for stage 4 (P = 0.001, log-rank test). The severity of EIFL was the only significant factor for time to evolution of EIFL ERM to a better stage, where the eyes with stage 4 EIFL ERM showed faster foveal contour improvement compared to those with stage 3 EIFL ERM (hazard ratio: 0.317, 95% confidence interval = 0.164-0.615, P = 0.001).Conclusion: On assessing preoperative factors, the preoperative EIFL stage emerged as the sole significant factor for EIFL ERM improvement to a better disease stage. This study reports some of the longest follow-up durations for patients undergoing PPV for EIFL ERM, and both functional and anatomical improvements were observed across all stages of EIFL, including in the advanced stage 4 EIFL ERM.","PeriodicalId":18740,"journal":{"name":"Middle East African Journal of Ophthalmology","volume":"30 2","pages":"72-79"},"PeriodicalIF":0.5000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238928/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Middle East African Journal of Ophthalmology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/meajo.meajo_51_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/4/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: The purpose of this study was to evaluate pre- and perioperative factors related to time for the evolution of ectopic inner foveal layers (EIFL) following pars plana vitrectomy (PPV) for epiretinal membrane (ERM) peeling.

Methods: This retrospective study included 81 consecutive eyes with idiopathic ERM that underwent vitrectomy surgery. Standard PPV + internal limiting membrane peeling was performed in all cases. A comprehensive ophthalmic examination was performed for all patients before and 1, 3, 6, and 12 months, and the last follow-up after surgery. We observed the postoperative improvement in EIFL severity in the short-term and longest follow-up and evaluated anatomical and functional improvement. Several parameters were assessed using the multivariate COX proportional hazard analysis.

Results: Eighty patients (81 eyes) with a mean age of 70.33 ± 7.75 years were followed for a mean of 34.37 ± 23.61 months, and 55.5% of eyes (45 eyes) with EIFL ERM showed improvement of foveal contour to a better stage at the last follow-up. The median estimated time for evolving to a better stage was 29.73 months for stage 2, 49.68 months for stage 3, and 38.67 months for stage 4 (P = 0.001, log-rank test). The severity of EIFL was the only significant factor for time to evolution of EIFL ERM to a better stage, where the eyes with stage 4 EIFL ERM showed faster foveal contour improvement compared to those with stage 3 EIFL ERM (hazard ratio: 0.317, 95% confidence interval = 0.164-0.615, P = 0.001).

Conclusion: On assessing preoperative factors, the preoperative EIFL stage emerged as the sole significant factor for EIFL ERM improvement to a better disease stage. This study reports some of the longest follow-up durations for patients undergoing PPV for EIFL ERM, and both functional and anatomical improvements were observed across all stages of EIFL, including in the advanced stage 4 EIFL ERM.

查看原文本刊更多论文

异位内眼窝视网膜膜摘除术的长期随访结果

目的：本研究旨在评估因视网膜外膜（ERM）剥离而进行玻璃体旁切除术（PPV）后，与异位眼窝内层（EIFL）演变时间相关的术前和围手术期因素：这项回顾性研究纳入了81只接受玻璃体切除手术的特发性ERM患者。所有病例均进行了标准 PPV + 内缘膜剥离术。术前、术后1个月、3个月、6个月、12个月以及最后一次随访时，对所有患者进行了全面的眼科检查。我们观察了术后短期和长期随访中 EIFL 严重程度的改善情况，并评估了解剖和功能改善情况。我们使用多变量 COX 比例危险分析评估了几个参数：80名患者（81眼）的平均年龄为（70.33±7.75）岁，平均随访时间为（34.37±23.61）个月，55.5%的EIFL ERM患者（45眼）在最后一次随访时眼窝轮廓改善到了较好的阶段。估计发展到较好阶段的中位时间为：2期 29.73 个月，3期 49.68 个月，4期 38.67 个月（P = 0.001，对数秩检验）。EIFL的严重程度是EIFL ERM向较好阶段演变时间的唯一显著因素，与EIFL ERM 3期的患者相比，EIFL ERM 4期的患者眼窝轮廓改善更快（危险比：0.317，95%置信区间=0.164-0.615，P=0.001）：结论：在评估术前因素时，术前EIFL分期是EIFL ERM好转至较佳疾病分期的唯一重要因素。该研究报告了对接受PPV治疗的EIFL ERM患者进行的一些最长的随访时间，观察到所有阶段的EIFL，包括晚期4期EIFL ERM，在功能和解剖学上都有所改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Middle East African Journal of Ophthalmology OPHTHALMOLOGY-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Middle East African Journal of Ophthalmology (MEAJO), published four times per year in print and online, is an official journal of the Middle East African Council of Ophthalmology (MEACO). It is an international, peer-reviewed journal whose mission includes publication of original research of interest to ophthalmologists in the Middle East and Africa, and to provide readers with high quality educational review articles from world-renown experts. MEAJO, previously known as Middle East Journal of Ophthalmology (MEJO) was founded by Dr Akef El Maghraby in 1993.