Rapid availability of ethylene glycol test results with enzymatic assay.

IF 3 3区医学 Q2 TOXICOLOGY

Clinical Toxicology Pub Date : 2024-08-01 Epub Date: 2024-07-15 DOI:10.1080/15563650.2024.2377281

Westin Huntbach, Michael Moss

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引用次数: 0

Abstract

Background: Ethylene glycol poisoning causes metabolic acidosis, organ injury, and death. Ethylene glycol testing is unavailable in many areas. Our laboratory uses an automated glycerol dehydrogenase enzymatic assay to screen for ethylene glycol. We sought to determine how often ethylene glycol results were available within 12 h of the first dose of fomepizole.

Methods: Records from a single poison center were reviewed from December 2016 to December 2019. Cases were identified by searching for cases that received fomepizole. Outcomes included whether results were available within 12 h, and the turnaround time from time of laboratory order to result.

Results: Of the 125 cases of suspected toxic alcohol poisoning identified, 73 had screening for ethylene glycol by enzymatic assay. Results were available within 12 h of the initial fomepizole dose in 58 (79%) cases with a median turnaround time of 391 min.

Discussion: We have demonstrated clinically acceptable turnaround times using an automated screening ethylene glycol assay. The major limitations include lack of approval for this test at this time, the use of voluntarily reported poison center data, and lack of assessment of patient outcomes.

Conclusion: Enzymatic screening for ethylene glycol yielded results within 12 h in 79% of cases.

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利用酶法快速提供乙二醇检测结果。

背景：乙二醇中毒会导致代谢性酸中毒、器官损伤和死亡。许多地区都无法进行乙二醇检测。我们的实验室使用甘油脱氢酶自动测定法来筛查乙二醇。我们试图确定在首次服用福美匹唑 12 小时内乙二醇检测结果的出现频率：我们回顾了 2016 年 12 月至 2019 年 12 月期间一家毒物中心的记录。通过搜索接受过福美唑的病例来确定病例。结果包括是否在 12 小时内得到结果，以及从实验室下单到得到结果的周转时间：在确定的 125 例疑似中毒性酒精中毒病例中，有 73 例通过酶法检测筛查乙二醇。有58例（79%）在首次服用福美匹唑后12小时内得到结果，中位周转时间为391分钟：讨论：我们利用乙二醇自动筛选测定法证明了临床上可接受的周转时间。讨论：我们利用乙二醇自动筛查测定法证明了临床上可接受的周转时间，其主要局限性包括该检测法目前尚未获得批准，使用的是毒物中心自愿报告的数据，以及缺乏对患者预后的评估：结论：79%的病例可在 12 小时内得出乙二醇酶筛查结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Toxicology 医学-毒理学

CiteScore

5.70

自引率

12.10%

发文量

148

审稿时长

4-8 weeks

期刊介绍： clinical Toxicology publishes peer-reviewed scientific research and clinical advances in clinical toxicology. The journal reflects the professional concerns and best scientific judgment of its sponsors, the American Academy of Clinical Toxicology, the European Association of Poisons Centres and Clinical Toxicologists, the American Association of Poison Control Centers and the Asia Pacific Association of Medical Toxicology and, as such, is the leading international journal in the specialty.