Antimicrobial peptides: Source, application and recent developments

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Process Biochemistry Pub Date : 2024-07-02 DOI:10.1016/j.procbio.2024.07.002

Dixita Chettri , Aruna Rani , Bhaskar Sharma , Manickam Selvaraj , Mohammed A. Assiri , Anil Kumar Verma

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引用次数: 0

Abstract

Antimicrobial peptides (AMPs) belong to a group of biomolecules found in various life forms and form an important part of their defense mechanisms. They are effective against bacteria, viruses, fungi, and other parasites and have been categorized into different classes based on their structure and mode of action. Given the current global threat of increasing microbial resistance towards the diverse range of antibiotics, these AMPs represent an alternative approach to treating various infectious diseases and other bodily disorders. Their host specificity and biocompatibility with negligible resistance to various pathogens make them a much-researched substance in modern medical sciences. From screening of various natural resources to in silico design of novel AMPs, numerous AMPs have been discovered, some of which are used for commercial applications. In addition, specialized databases have been established to maintain information on these AMPs, and their fusion with other innovations, such as nanotechnology, has been accomplished. AMPs are also used in the food industry for packaging, and their application in other areas can be further explored and optimized for therapeutic purposes.

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抗菌肽：来源、应用和最新发展

抗菌肽（AMPs）属于一组生物大分子，存在于各种生命形式中，是其防御机制的重要组成部分。它们对细菌、病毒、真菌和其他寄生虫有效，并根据其结构和作用方式分为不同的类别。鉴于目前全球微生物对各种抗生素的抗药性不断增加的威胁，这些 AMPs 代表了治疗各种传染病和其他身体疾病的另一种方法。它们具有宿主特异性和生物兼容性，对各种病原体的抗药性几乎可以忽略不计，这使它们成为现代医学科学中备受研究的物质。从各种自然资源的筛选到新型 AMPs 的硅学设计，已经发现了许多 AMPs，其中一些已用于商业用途。此外，还建立了专门的数据库来保存这些 AMPs 的信息，并将其与其他创新技术（如纳米技术）相融合。AMPs 还被用于食品工业的包装，其在其他领域的应用还可以进一步探索和优化，以达到治疗目的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Process Biochemistry 生物-工程：化工

CiteScore

8.30

自引率

4.50%

发文量

374

审稿时长

53 days

期刊介绍： Process Biochemistry is an application-orientated research journal devoted to reporting advances with originality and novelty, in the science and technology of the processes involving bioactive molecules and living organisms. These processes concern the production of useful metabolites or materials, or the removal of toxic compounds using tools and methods of current biology and engineering. Its main areas of interest include novel bioprocesses and enabling technologies (such as nanobiotechnology, tissue engineering, directed evolution, metabolic engineering, systems biology, and synthetic biology) applicable in food (nutraceutical), healthcare (medical, pharmaceutical, cosmetic), energy (biofuels), environmental, and biorefinery industries and their underlying biological and engineering principles.