HLA-DM and HLA-DO interplay for the peptide editing of HLA class II in healthy tissues and leukemia

IF 2.2 4区 医学 Q3 HEMATOLOGY
Bettina Budeus , Miguel Álvaro-Benito , Pietro Crivello
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引用次数: 0

Abstract

HLA class II antigen presentation is modulated by the activity of the peptide editor HLA-DM and its antagonist HLA-DO, with their interplay controlling the peptide repertoires presented by normal and malignant cells. The role of these molecules in allogeneic hematopoietic cell transplantation (alloHCT) is poorly investigated. Balanced expression of HLA-DM and HLA-DO can influence the presentation of leukemia-associated antigens and peptides targeted by alloreactive T cells, therefore affecting both anti-leukemia immunity and the potential onset of Graft versus Host Disease. We leveraged on a large collection of bulk and single cell RNA sequencing data, available at different repositories, to comprehensively review the level and distribution of HLA-DM and HLA-DO in different cell types and tissues of the human body. The resulting expression atlas will help future investigations aiming to dissect the dual role of HLA class II peptide editing in alloHCT, and their potential impact on its clinical outcome.

健康组织和白血病中 HLA II 类多肽编辑的 HLA-DM 和 HLA-DO 相互作用
HLA II 类抗原呈递受肽编辑器 HLA-DM 及其拮抗剂 HLA-DO 的活性调节,它们之间的相互作用控制着正常细胞和恶性细胞呈递的肽库。这些分子在异基因造血细胞移植(alloHCT)中的作用尚未得到充分研究。HLA-DM 和 HLA-DO 的平衡表达会影响白血病相关抗原和异体活性 T 细胞靶向肽的表达,从而影响抗白血病免疫和移植物抗宿主疾病的潜在发病。我们利用不同资料库中的大量体细胞和单细胞 RNA 测序数据,全面研究了 HLA-DM 和 HLA-DO 在人体不同细胞类型和组织中的水平和分布。所绘制的表达图谱将有助于未来的研究,旨在剖析 HLA II 类多肽编辑在异体肝移植中的双重作用及其对临床结果的潜在影响。
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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.
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