Lei Zhu, Shunlong Meng, Longxiang Fang, Zhonghua Li, Ruonan Yang, Liping Qiu, Liqiang Zhong, Chao Song
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引用次数: 0
Abstract
The increasing use and abuse of antibiotics in agriculture and aquaculture necessitates a more thorough risk assessment. We first advocate a precise assessment that subdivides the assessment scope from interspecies to intraspecific levels. Differences in ENR residues and degradation within the intraspecific category were simultaneously explored. This study chose red and GIFT tilapia, both belonging to the intra-specific category of tilapia, for an enrofloxacin (ENR) exposure experiment. Red tilapia had a lower area under the curve (AUC) representing drug accumulation, indicating a notably shorter withdrawal period (7 days) compared to GIFT tilapia (31.4 days) in the edible parts. While four potential transformation pathways were proposed for ENR in tilapia, red tilapia had fewer detected degradation products (6 items) than GIFT tilapia (10 items), indicating a simpler transformation pathway in red tilapia. Predictive assessments using the Toxtree model revealed that of the four extra degradation products in GIFT tilapia, two may possess carcinogenic and mutagenic properties. Overall, differences were observed in ENR residues and degradation within the intraspecific category, with red tilapia presenting lower risks than GIFT tilapia. This work suggests a new strategy to perfect the methodology for antibiotic risk assessment and facilitate systematic antibiotic administration management in the future.
随着抗生素在农业和水产养殖业中的使用和滥用日益增多,有必要进行更全面的风险评估。我们首先提倡精确评估,将评估范围从种间水平细分到种内水平。同时,我们还探讨了ENR在种内类别中的残留和降解差异。本研究选择了属于罗非鱼种内类别的红罗非鱼和GIFT罗非鱼进行恩诺沙星(ENR)暴露实验。与 GIFT 罗非鱼(31.4 天)相比,红罗非鱼可食用部分的药物累积曲线下面积(AUC)较低,表明其停药期(7 天)明显较短。虽然提出了罗非鱼 ENR 的四种潜在转化途径,但红罗非鱼检测到的降解产物(6 项)少于 GIFT 罗非鱼(10 项),表明红罗非鱼的转化途径更简单。使用 Toxtree 模型进行的预测评估显示,在 GIFT 罗非鱼多出的四种降解产物中,有两种可能具有致癌和致突变特性。总体而言,在种内类别中观察到 ENR 残留和降解的差异,红罗非鱼的风险低于 GIFT 罗非鱼。这项工作为完善抗生素风险评估方法和促进未来系统化抗生素用药管理提出了新的策略。