Paradoxical keratitis and dermatitis following adalimumab treatment

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01 DOI:10.1016/j.jaapos.2024.103970

Noor Ghali MS , Arif O. Khan MD

引用次数: 0

Abstract

Anti-tumor necrosis factor monoclonal antibodies are an important tool in the management of rheumatologic disease. However, paradoxical inflammation can be precipitated by their use. This case report describes the development of keratitis and dermatitis following adalimumab treatment for chronic recurrent multifocal osteomyelitis in a 6-year-old girl. The keratitis and dermatitis subsided once topical steroids were started and the adalimumab was held.

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阿达木单抗治疗后出现的矛盾性角膜炎和皮炎。

抗肿瘤坏死因子（TNF）单克隆抗体是治疗风湿病的重要工具。然而，使用这种抗体可能会诱发矛盾性炎症。本病例报告描述了一名6岁女孩在接受阿达木单抗治疗慢性复发性多灶性骨髓炎后出现角膜炎和皮炎的情况。在开始使用外用类固醇并停用阿达木单抗后，角膜炎和皮炎均已消退。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.