Exploiting the potential of dupilumab in the treatment of eosinophilic COPD.

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-07-12 DOI:10.1016/j.medj.2024.05.011

Maria Gabriella Matera, Mario Cazzola

引用次数: 0

Abstract

Chronic obstructive pulmonary disease (COPD) often involves type 1 (T1) inflammation, but 40% of patients have T2 inflammation, which worsens outcomes. Dupilumab, targeting interleukin (IL)-4 and IL-13, shows promise in phase 3 trials. The new NOTUS trial¹ showed effectiveness in reducing exacerbations and improving lung function. However, its predominantly white population limits generalizability. Future research should include diverse populations and assess different therapies combined with dupilumab to improve outcomes.

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挖掘杜匹单抗治疗嗜酸性粒细胞慢性阻塞性肺病的潜力。

慢性阻塞性肺病（COPD）常伴有1型（T1）炎症，但40%的患者伴有T2型炎症，这会恶化预后。针对白细胞介素（IL）-4和IL-13的Dupilumab在3期试验中显示出良好的前景。新的 NOTUS 试验1 显示，该疗法在减少病情恶化和改善肺功能方面具有疗效。然而，该试验的主要受试者为白人，这限制了试验的普遍性。未来的研究应包括不同的人群，并评估不同疗法与杜必鲁单抗的结合，以改善疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

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