Intracellular calcium dysregulation in heart and brain diseases: Insights from induced pluripotent stem cell studies.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Neuropathology and Experimental Neurology Pub Date : 2024-12-01 DOI:10.1093/jnen/nlae078

Huayang Zhang, Xueming Ren, Chunyu Wu, Xinsen He, Zhengxuan Huang, Yangpeng Li, Lei Liao, Jie Xiang, Miaoling Li, Lin Wu

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引用次数: 0

Abstract

The central nervous system (CNS) plays a role in regulating heart rate and myocardial contractility through sympathetic and parasympathetic nerves, and the heart can impact the functional equilibrium of the CNS through feedback signals. Although heart and brain diseases often coexist and mutually influence each other, the potential links between heart and brain diseases remain unclear due to a lack of reliable models of these relationships. Induced pluripotent stem cells (iPSCs), which can differentiate into multiple functional cell types, stem cell biology and regenerative medicine may offer tools to clarify the mechanisms of these relationships and facilitate screening of effective therapeutic agents. Because calcium ions play essential roles in regulating both the cardiovascular and nervous systems, this review addresses how recent iPSC disease models reveal how dysregulation of intracellular calcium might be a common pathological factor underlying the relationships between heart and brain diseases.

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心脏和大脑疾病中的细胞内钙失调：诱导多能干细胞研究的启示。

中枢神经系统（CNS）通过交感神经和副交感神经调节心率和心肌收缩力，心脏可通过反馈信号影响中枢神经系统的功能平衡。虽然心脏和大脑疾病经常并存并相互影响，但由于缺乏可靠的模型来研究这些关系，心脏和大脑疾病之间的潜在联系仍不清楚。诱导多能干细胞（iPSC）可分化为多种功能细胞类型，干细胞生物学和再生医学可为阐明这些关系的机制提供工具，并促进有效治疗药物的筛选。由于钙离子在调节心血管系统和神经系统中发挥着重要作用，本综述将探讨最近的iPSC疾病模型如何揭示细胞内钙失调可能是心脏和大脑疾病之间关系的共同病理因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuropathology and Experimental Neurology 医学-病理学

CiteScore

5.40

自引率

6.20%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Journal of Neuropathology & Experimental Neurology is the official journal of the American Association of Neuropathologists, Inc. (AANP). The journal publishes peer-reviewed studies on neuropathology and experimental neuroscience, book reviews, letters, and Association news, covering a broad spectrum of fields in basic neuroscience with an emphasis on human neurological diseases. It is written by and for neuropathologists, neurologists, neurosurgeons, pathologists, psychiatrists, and basic neuroscientists from around the world. Publication has been continuous since 1942.