Platelet-Rich Plasma for Knee and Hip Osteoarthritis Pain: A Scoping Review.

IF 2.9 2区 医学 Q1 ORTHOPEDICS
Grace Tanguilig, Jaydeep Dhillon, Matthew J Kraeutler
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Abstract

Purpose of review: Platelet-rich plasma (PRP) is an emerging biological intervention for osteoarthritis (OA), yet the outcomes remain uncertain. The purpose of this study was to review current literature regarding the use of PRP for knee and hip OA.

Recent findings: Recent systematic reviews have found significant clinical improvements in outcomes after the administration of PRP compared to hyaluronic acid (HA) in patients with knee OA. One of these reviews included bone marrow aspirate concentrate (BMAC) as a comparison group and found no significant differences in outcomes between PRP and BMAC. Currently, the literature is lacking on whether leukocyte-rich or leukocyte-poor PRP is superior in patients with knee OA. The literature on PRP for hip OA has not provided consistent results as it has for the knee. Two recent systematic reviews evaluated RCTs for patients undergoing treatment with either PRP or HA for hip OA and found no significant differences in clinical outcomes between groups at final follow-up. Current literature regarding the association between OA grade and PRP efficacy has found varying results. The use of PRP injections in the treatment of knee OA appears to be favorable, resulting in clinically comparable or superior outcomes compared to other injection treatments. However, the clinical efficacy of PRP injections in hip OA is far less consistent. Evidence is lacking to suggest that the presence of leukocytes significantly influences clinical outcomes. Further randomized controlled trials on larger cohorts, with longer follow-up, and with comparable formulations are required before recommendations can be made regarding use of PRP for hip OA, the effect of leukocyte concentration, and clinical efficacy based on OA grade.

富血小板血浆治疗膝关节和髋关节骨性关节炎疼痛:范围界定综述。
综述目的:富血小板血浆(PRP)是治疗骨关节炎(OA)的一种新兴生物干预方法,但其结果仍不确定。本研究旨在回顾目前有关使用富血小板血浆治疗膝关节和髋关节 OA 的文献:最近的系统性综述发现,与透明质酸(HA)相比,在膝关节 OA 患者中使用 PRP 后,临床疗效显著改善。其中一篇综述将骨髓抽吸物浓缩物(BMAC)作为对比组,结果发现 PRP 和 BMAC 的疗效无明显差异。目前,关于富含白细胞的 PRP 还是贫乏白细胞的 PRP 更适合膝关节 OA 患者的文献尚缺。有关 PRP 治疗髋关节 OA 的文献并没有像膝关节那样提供一致的结果。最近的两篇系统性综述对接受 PRP 或 HA 治疗髋关节 OA 的患者进行了 RCT 评估,结果发现在最终随访时,不同组间的临床疗效无明显差异。目前有关 OA 等级与 PRP 疗效之间关系的文献发现了不同的结果。使用 PRP 注射治疗膝关节 OA 似乎是有利的,与其他注射疗法相比,其临床疗效相当或更佳。然而,PRP 注射治疗髋关节 OA 的临床疗效却不那么一致。缺乏证据表明白细胞的存在会显著影响临床效果。在就 PRP 用于髋关节 OA、白细胞浓度的影响以及基于 OA 等级的临床疗效提出建议之前,还需要对更大的群体、更长的随访时间以及可比较的配方进行进一步的随机对照试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.50
自引率
2.40%
发文量
64
期刊介绍: This journal intends to review the most significant recent developments in the field of musculoskeletal medicine. By providing clear, insightful, balanced contributions by expert world-renowned authors, the journal aims to serve all those involved in the diagnosis, treatment, management, and prevention of musculoskeletal-related conditions. We accomplish this aim by appointing authorities to serve as Section Editors in key subject areas, such as rehabilitation of the knee and hip, sports medicine, trauma, pediatrics, health policy, customization in arthroplasty, and rheumatology. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 20 diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.
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