Health economic evaluation of topical treatments for external anogenital warts.

IF 3.1 4区医学 Q2 DERMATOLOGY

Annales De Dermatologie Et De Venereologie Pub Date : 2024-09-01 Epub Date: 2024-07-15 DOI:10.1016/j.annder.2024.103288

H Agbeci, O Rollot, C Derancourt, Q Baglione, A Benard, A Bertolotti

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引用次数: 0

Abstract

Introduction: No treatment hierarchy for external anogenital warts (AGW) is currently recommended, despite wide variations in the costs of available treatments. The aim of this study was to propose a treatment hierarchy based on a health economic analysis of local treatments for AGW from the perspective of the French health insurance system.

Methods: Thirteen treatments and 73 treatment sequences were evaluated for AGW clearance and absence of AGW recurrence at 3 months of follow-up. The cost per treatment included the cost of consultations, drugs, medical procedures, and dressings. The time horizon was one year. The least expensive treatment was used as the reference treatment in the calculation of incremental cost-effectiveness ratios (ICERs). A two-line decision tree for treatment was constructed.

Results: Podophyllotoxin 0.5% solution was the least expensive treatment. Compared to podophyllotoxin 0.5% solution, the most cost-effective treatment was surgical excision (ICER: €456.82) and the most cost-effective treatment sequence was podophyllotoxin 0.5% solution followed by 5-fluorouracil (5-FU) 5% cream.

Conclusion: Considering the high risk of bias in the randomized controlled trials considered, the most cost-effective treatment sequence was podophyllotoxin 0.5% solution followed by 5-FU 5% cream.

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外生殖器疣局部治疗的卫生经济评估。

导言：尽管现有的外生殖器疣（AGW）治疗方法成本差异很大，但目前并没有建议采用分级治疗方法。本研究的目的是从法国医疗保险体系的角度出发，根据对外生殖器疣局部治疗的卫生经济学分析，提出治疗分级：方法：对 13 种治疗方法和 73 个治疗序列进行了评估，以确定 AGW 是否清除，以及随访 3 个月后 AGW 是否复发。每次治疗的费用包括咨询费、药费、医疗程序费和敷料费。时间跨度为一年。在计算增量成本效益比（ICER）时，将成本最低的治疗方法作为参考治疗方法。构建了一个双线治疗决策树：结果：0.5%的鬼臼毒素溶液是成本最低的治疗方法。与荚叶素 0.5%溶液相比，最具成本效益的治疗方法是手术切除（ICER：456.82 欧元），最具成本效益的治疗顺序是荚叶素 0.5%溶液，然后是 5-氟尿嘧啶（5-FU）5% 乳膏：考虑到随机对照试验的高偏倚风险，最具成本效益的治疗顺序是先用0.5%的荚叶托品溶液，再用5%的5-氟尿嘧啶（5-FU）乳膏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annales De Dermatologie Et De Venereologie 医学-皮肤病学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Les Annales de dermatologie sont le rendez-vous mensuel incontournable de toute la dermatologie francophone, grâce à leur comité de rédaction qui assure une sélection rigoureuse des articles selon les normes de l''édition scientifique internationale. Une revue didactique, véritable aide à la pratique médicale quotidienne Pour compléter et enrichir la partie scientifique, la rubrique Formation médicale continue propose aux lecteurs des textes didactiques et interactifs (Cas pour diagnostic, Notes de pharmacovigilance, la Question du praticien, Dermatologie chirurgicale, la Sélection bibliographique du mois...) qui les font bénéficier d''une formation post-universitaire diversifiée et de qualité. La revue consacre également un espace pour la publication de questions des lecteurs auxquelles des experts apportent une réponse.