Association of TyG index with aortic valve calcification in valvular heart disease patients.

IF 3.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Postgraduate Medical Journal Pub Date : 2024-07-13 DOI:10.1093/postmj/qgae085

Peiyu Wang, Yiyao Zeng, Li Wang, Yufeng Jiang, Jinsheng Shen, Fulu Jin, Yafeng Zhou, Liangping Zhao

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引用次数: 0

Abstract

Background: In recent years, triglyceride glucose (TyG) index, as a popular metabolic index, has been proposed as an alternative index of insulin resistance, and it has been proved to be associated with many cardiovascular diseases, but the relationship between it and aortic valve calcification is still unknown.

Methods: A total of 450 aortic valve disease patients were enrolled in this study, including 361 patients with aortic valve calcification (AVC) (calcification group) and 89 patients without (control group). According to the severity of AVC, patients with AVC included severe calcification, moderate calcification and low calcification. The TyG index was calculated based on fasting triglyceride and fasting blood glucose levels.

Results: The TyG index in the calcification group was significantly higher than that in the control group (P < .05), and with the increase of the degree of calcification, the TyG index showed an increasing trend. The univariate and multivariate logistic regression analysis showed TyG index has a high predictive value for the presence of AVC (OR (95% CI): 1.743 (1.036-2.933)) and severe AVC (OR (95% CI): 1.608 (1.143-2.262)). In assessing the predictive value of the TyG index distribution width for AVC, with the first quartile as a reference, the last quartile of the TyG index had significant predictive value for the presence of AVC and severe AVC.

Conclusions: TyG index was significantly associated with the presence and severity of AVC, suggesting that TyG index may be a valid predictor of AVC.

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TyG指数与瓣膜性心脏病患者主动脉瓣钙化的关系

背景：近年来，甘油三酯血糖（TyG）指数作为一种流行的代谢指标，被提出作为胰岛素抵抗的替代指标，并被证实与多种心血管疾病相关，但其与主动脉瓣钙化的关系尚不清楚：本研究共纳入了 450 名主动脉瓣疾病患者，包括 361 名主动脉瓣钙化（AVC）患者（钙化组）和 89 名未钙化患者（对照组）。根据主动脉瓣钙化的严重程度，主动脉瓣钙化患者包括重度钙化、中度钙化和低度钙化。根据空腹甘油三酯和空腹血糖水平计算TyG指数：钙化组的 TyG 指数明显高于对照组（P 结论：钙化组的 TyG 指数明显高于对照组（P）：TyG指数与AVC的存在和严重程度明显相关，表明TyG指数可能是预测AVC的有效指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Postgraduate Medical Journal 医学-医学：内科

CiteScore

8.50

自引率

2.00%

发文量

131

审稿时长

2.5 months

期刊介绍： Postgraduate Medical Journal is a peer reviewed journal published on behalf of the Fellowship of Postgraduate Medicine. The journal aims to support junior doctors and their teachers and contribute to the continuing professional development of all doctors by publishing papers on a wide range of topics relevant to the practicing clinician and teacher. Papers published in PMJ include those that focus on core competencies; that describe current practice and new developments in all branches of medicine; that describe relevance and impact of translational research on clinical practice; that provide background relevant to examinations; and papers on medical education and medical education research. PMJ supports CPD by providing the opportunity for doctors to publish many types of articles including original clinical research; reviews; quality improvement reports; editorials, and correspondence on clinical matters.