Botanical extract combined with minoxidil improve hidrotic ectodermal dysplasia caused by p.G11R mutations: a case report.

Shiyi Zhong, Chuhan Huang, Mingyue Zhuang, Qingwu Liu, Ziyuan Tian, Dingquan Yang
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Abstract

Purpose: We aim to explore a potential treatment strategy for hair loss.

Materials and methods: A male 6-year-old child was diagnosed with hidrotic ectodermal dysplasia 2 (HED2) caused by GJB6 (p.G11R) mutations. He presented at our clinic with diffuse thinning and fine and brittle hair since birth. Additionally, the child exhibited abnormal development of teeth, fingernails, and toenails. The condition of the child's hair had not improved significantly with age. He was treated with botanical extracts combined with Minoxidil.

Results: After one and a half months of treatment, the patient showed remarkable hair growth.

Conclusions: Our team has previously used botanical extracts in combination for the treatment of autosomal recessive wooly hair in children. In the present case, treatment with botanical extract combined with minoxidil was found to be equally efficacious. This case report provides valuable information for future studies on the use of botanical extracts in treating hair loss, as well as a safe and effective potential treatment strategy for children with congenital alopecia.

植物提取物与米诺地尔联合治疗 p.G11R 突变引起的潮解性外胚层发育不良:病例报告。
目的:我们旨在探索脱发的潜在治疗策略:一名 6 岁男童被诊断患有由 GJB6(p.G11R)突变引起的潮解性外胚层发育不良 2(HED2)。他自出生起就出现头发弥漫性稀疏、细脆等症状,并到我院就诊。此外,患儿的牙齿、指甲和脚趾甲发育异常。随着年龄的增长,孩子的头发状况也没有明显改善。他接受了植物提取物和米诺西地联合治疗:经过一个半月的治疗,患者的头发明显生长:我们的团队曾使用植物提取物联合治疗儿童常染色体隐性毛发。在本病例中,我们发现植物提取物联合米诺地尔治疗同样有效。本病例报告为今后使用植物提取物治疗脱发的研究提供了有价值的信息,同时也为患有先天性脱发的儿童提供了一种安全有效的潜在治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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