The role of fecal biomarkers in individuals with inflammatory bowel disease.

IF 3.9 3区医学 Q1 PATHOLOGY

Expert Review of Molecular Diagnostics Pub Date : 2024-06-01 Epub Date: 2024-07-12 DOI:10.1080/14737159.2024.2375224

Teagan S Edwards, Andrew S Day

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引用次数: 0

Abstract

Introduction: Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and Ulcerative Colitis (UC), is a relapsing and remitting condition. Noninvasive biomarkers have an increasingly important role in the diagnosis of IBD and in the prediction of future disease course in individuals with IBD. Strategies for the management of IBD increasingly rely upon close monitoring of gastrointestinal inflammation.

Areas covered: This review provides an update on the current understanding of established and novel stool-based biomarkers in the diagnosis and management of IBD. It also highlights key gaps, identifies limitations, and advantages of current markers, and examines aspects that require further study and analysis.

Expert opinion: Current noninvasive inflammatory markers play an important role in the diagnosis and management of IBD; however, limitations exist. Future work is required to further characterize and validate current and novel markers of inflammation. In addition, it is essential to better understand the roles and characteristics of noninvasive markers to enable the appropriate selection to accurately determine the condition of the intestinal mucosa.

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粪便生物标志物在炎症性肠病患者中的作用。

简介炎症性肠病（IBD）包括克罗恩病（CD）和溃疡性结肠炎（UC），是一种复发性和缓解性疾病。非侵入性生物标志物在诊断 IBD 和预测 IBD 患者未来病程方面发挥着越来越重要的作用。IBD的治疗策略越来越依赖于对胃肠道炎症的密切监测：本综述介绍了目前对 IBD 诊断和管理中基于粪便的成熟和新型生物标记物的最新认识。专家观点：目前的非侵入性炎症标志物在诊断和治疗 IBD 中发挥着重要作用：当前的非侵入性炎症标记物在 IBD 的诊断和管理中发挥着重要作用，但也存在局限性。未来的工作需要进一步描述和验证现有的和新型的炎症标记物。此外，还必须更好地了解非侵入性标记物的作用和特点，以便选择适当的标记物来准确判断肠粘膜的状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Molecular Diagnostics 医学-病理学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Expert Review of Molecular Diagnostics (ISSN 1473-7159) publishes expert reviews of the latest advancements in the field of molecular diagnostics including the detection and monitoring of the molecular causes of disease that are being translated into groundbreaking diagnostic and prognostic technologies to be used in the clinical diagnostic setting. Each issue of Expert Review of Molecular Diagnostics contains leading reviews on current and emerging topics relating to molecular diagnostics, subject to a rigorous peer review process; editorials discussing contentious issues in the field; diagnostic profiles featuring independent, expert evaluations of diagnostic tests; meeting reports of recent molecular diagnostics conferences and key paper evaluations featuring assessments of significant, recently published articles from specialists in molecular diagnostic therapy. Expert Review of Molecular Diagnostics provides the forum for reporting the critical advances being made in this ever-expanding field, as well as the major challenges ahead in their clinical implementation. The journal delivers this information in concise, at-a-glance article formats: invaluable to a time-constrained community.