Effectiveness of platelet-rich plasma in long-lasting post-viral olfactory dysfunction: a case-series.

IF 1.9 3区医学 Q2 OTORHINOLARYNGOLOGY

European Archives of Oto-Rhino-Laryngology Pub Date : 2024-11-01 Epub Date: 2024-07-11 DOI:10.1007/s00405-024-08816-5

Jerome R Lechien, Sven Saussez

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Abstract

Objective: To investigate the platelet-rich plasma (PRP) effectiveness in patients with a long-lasting postviral olfactory dysfunction (LPOD).

Methods: Forty-three consecutive patients with a long-lasting postviral OD were prospectively recruited. The injection of 1 mL of PRP was carried out in both olfactory clefts. The pre- to 6-month post-PRP injection change in olfaction was assessed with the olfactory disorder questionnaire (ODQ) and the threshold, discrimination, and identification (TDI) tests.

Results: Forty-three patients received bilateral PRP injections (24 females). The mean age of patients was 58.9 ± 16.8 years. The mean duration of LPOD was 8.7 years. The pre to 6-month post-injection mean TDI significantly improved from 10.3 ± 10.2 to 20.12 ± 12.07 (p = 0.001). The mean ODQ significantly decreased from 29.8 ± 13.0 to 23.4 ± 11.3 (p = 0.013). The average change of the TDI and the ODQ were 9.8 and 6.4, respectively. Age was inversely associated with the 6-month threshold score.

Conclusion: PRP appears to be a promising therapeutic strategy for long-lasting postviral OD. Our findings support the conduction of controlled randomized trial in this population of patients.

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富血小板血浆对病毒后长期嗅觉功能障碍的疗效：病例系列。

目的研究富血小板血浆（PRP）对病毒后长期嗅觉障碍（LPOD）患者的疗效：前瞻性地招募了 43 名连续的病毒后长期嗅觉障碍患者。在双侧嗅裂注射 1 mL PRP。通过嗅觉障碍问卷（ODQ）和阈值、辨别力和识别力（TDI）测试，评估了注射 PRP 后 6 个月嗅觉的变化：43名患者接受了双侧PRP注射（24名女性）。患者的平均年龄为（58.9 ± 16.8）岁。LPOD的平均持续时间为8.7年。注射前到注射后 6 个月的平均 TDI 从 10.3 ± 10.2 显著提高到 20.12 ± 12.07（p = 0.001）。平均 ODQ 从 29.8 ± 13.0 显著降至 23.4 ± 11.3（p = 0.013）。TDI和ODQ的平均变化分别为9.8和6.4。年龄与6个月阈值得分成反比：PRP似乎是治疗病毒后长期OD的一种很有前景的治疗策略。我们的研究结果支持在这类患者中开展随机对照试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Oto-Rhino-Laryngology 医学-耳鼻喉科学

CiteScore

5.30

自引率

7.70%

发文量

537

审稿时长

2-4 weeks

期刊介绍： Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.