Nanoarchitectonics for synergistic activity of multimetallic nanohybrids as a possible approach for antimicrobial resistance (AMR)

IF 2.7 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

JBIC Journal of Biological Inorganic Chemistry Pub Date : 2024-07-12 DOI:10.1007/s00775-024-02066-w

Piumika N. Yapa, Imalka Munaweera, Manjula M. Weerasekera, Laksiri Weerasinghe

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Abstract

The global threat posed by antimicrobial resistance (AMR) to public health is an immensurable problem. The effectiveness of treating infections would be more at risk in the absence of effective antimicrobials. Researchers have shown an amplified interest in alternatives, such as developing advanced metallic nanohybrids as new therapeutic candidates for antibiotics due to their promising effectiveness against resistant microorganisms. In recent decades, the antimicrobial activity of monometallic nanoparticles has received extensive study and solid proof, providing new opportunities for developing multimetallic nanohybrid antimicrobials. Advanced metallic nanohybrids are an emerging remedy for a number of issues that develop in the field of medicine. Advanced metallic nanohybrids have shown a promising ability to combat resistant microorganisms due to their overall synergistic activity. Formulating advanced multimetallic nanohybrids falling under the umbrella of the growing field of nanoarchitectonics, which extends beyond nanotechnology. The underlying theory of nanoarchitectonics involves utilizing nanoscale units that follow the concepts of nanotechnology to architect nanomaterials. This review focuses on a comprehensive description of antimicrobial mechanisms of metallic nanohybrids and their enabling future insights on the research directions of developing the nanoarchitectonics of advanced multimetallic nanohybrids as novel antibiotics through their synergistic activity.

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多金属纳米混合物的纳米结构协同活性，作为抗菌剂耐药性 (AMR) 的一种可能方法。

抗菌药耐药性（AMR）对全球公共卫生构成的威胁是一个无法估量的问题。如果没有有效的抗菌药物，治疗感染的效果将面临更大的风险。研究人员对替代品表现出了更大的兴趣，例如开发先进的金属纳米混合物，作为抗生素的新治疗候选药物，因为它们对抗药性微生物具有良好的疗效。近几十年来，单金属纳米粒子的抗菌活性得到了广泛的研究和确凿的证明，这为开发多金属纳米杂化抗菌剂提供了新的机遇。先进的金属纳米杂化物是解决医学领域一系列问题的新兴疗法。先进的金属纳米杂化物由于其整体协同活性，在抗击耐药性微生物方面表现出良好的能力。先进多金属纳米混合物的配制属于不断发展的纳米建筑学领域的范畴，它超越了纳米技术的范畴。纳米建筑学的基本理论是利用纳米级单元，按照纳米技术的概念来建筑纳米材料。本综述侧重于全面描述金属纳米杂化物的抗菌机理，以及通过其协同活性将先进的多金属纳米杂化物开发为新型抗生素的纳米建筑学研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JBIC Journal of Biological Inorganic Chemistry 化学-生化与分子生物学

CiteScore

5.90

自引率

3.30%

发文量

审稿时长

3 months

期刊介绍： Biological inorganic chemistry is a growing field of science that embraces the principles of biology and inorganic chemistry and impacts other fields ranging from medicine to the environment. JBIC (Journal of Biological Inorganic Chemistry) seeks to promote this field internationally. The Journal is primarily concerned with advances in understanding the role of metal ions within a biological matrix—be it a protein, DNA/RNA, or a cell, as well as appropriate model studies. Manuscripts describing high-quality original research on the above topics in English are invited for submission to this Journal. The Journal publishes original articles, minireviews, and commentaries on debated issues.