Is a vegetarian diet beneficial for bipolar disorder? Relationship between dietary patterns, exercise and pharmacological treatments with metabolic syndrome and course of disease in bipolar disorder

IF 5.3 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2024-07-12 DOI:10.1111/acps.13733

Susana Gomes-da-Costa, Isabel Fernandéz-Pérez, Roger Borras, Noelia Lopez, Yudith Rivas, Victoria Ruiz, Maria Teresa Pons-Cabrera, Anna Giménez-Palomo, Gerard Anmella, Marc Valentí, Michael Berk, Eduard Vieta, Isabella Pacchiarotti

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引用次数: 0

Abstract

Background

Lifestyle factors are being increasingly studied in bipolar disorder (BD) due to their possible effects on both course of disease and physical health. The aim of this study was to jointly describe and explore the interrelations between diet patterns, exercise, pharmacological treatment with course of disease and metabolic profile in BD.

Methods

The sample consisted of 66 euthymic or mild depressive individuals with BD. Clinical and metabolic outcomes were assessed, as well as pharmacological treatment or lifestyle habits (diet and exercise). Correlations were explored for different interrelations and a factor analysis of dietary patterns was performed.

Results

Adherence to the Mediterranean diet was low, seen in 37.9% of the patients and was positively associated with perceived quality of life. The amount of exercise was negatively associated with cholesterol levels, with 32.8% of participants rated as low active by International Physical Activity Questionnaire. There was a high prevalence of obesity (40.6%) and metabolic syndrome (29.7%). Users of lithium showed the best metabolic profile. Interestingly, three dietary patterns were identified: “vegetarian,” “omnivore” and “Western.” The key finding was the overall positive impact of the “vegetarian” pattern in BD, which was associated with reduced depression scores, better psychosocial functioning, and perceived quality of life, decreased body mass index, cholesterol, LDL and diastolic blood pressure. Nuts consumption was associated with a better metabolic profile.

Conclusions

A vegetarian diet pattern was associated with both, better clinical and metabolic parameters, in patients with BD. Future studies should prioritize prospective and randomized designs to determine causal relationships, and potentially inform clinical recommendations.

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素食对躁郁症有益吗？躁郁症患者的饮食模式、运动和药物治疗与代谢综合征和病程之间的关系。

背景：由于生活方式可能对躁狂症（BD）的病程和身体健康产生影响，人们对其进行了越来越多的研究。本研究旨在共同描述和探讨饮食模式、运动、药物治疗与躁狂症病程和代谢状况之间的相互关系：方法：研究样本包括 66 名抑郁症患者或轻度抑郁症患者。对临床和代谢结果以及药物治疗或生活习惯（饮食和运动）进行了评估。研究人员探讨了不同相互关系，并对饮食模式进行了因子分析：结果：37.9%的患者坚持地中海饮食，但坚持率较低，且与生活质量呈正相关。运动量与胆固醇水平呈负相关，32.8%的参与者在国际体育活动问卷调查中被评为运动量低。肥胖（40.6%）和代谢综合征（29.7%）的发病率很高。锂盐使用者的代谢状况最好。有趣的是，研究发现了三种饮食模式："素食"、"杂食 "和 "西式"。主要发现是 "素食 "模式对 BD 的整体积极影响，它与抑郁评分降低、社会心理功能改善、生活质量感知提高、体重指数、胆固醇、低密度脂蛋白和舒张压降低有关。食用坚果与更好的代谢状况有关：结论：素食模式与 BD 患者更好的临床和代谢指标相关。未来的研究应优先考虑前瞻性和随机设计，以确定因果关系，并为临床建议提供潜在依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.