[Effect of GABA-linoleamide and glycine linoleamide on pentamethylenetetrazole convulsions].

Abstract

We have studied the effect of GABA-linoleamide (GL) (100 mg/kg i.p.) and glycine-linoleamide (LG) (70 mg/kg i.p.), on the pentamethylenetetrazole (PTZ) (82 mg/kg i.p.) convulsions and lethality of rats. LG antagonize more efficiently than GL the PTZ convulsions and lethality. In another experiment, rats have received haloperidol (2 mg/kg i.p.) for 12 days. Four days after the last administration of haloperidol, rats received as previously GL (100 mg/kg i.p.) or LG (70 mg/kg i.p.) and PTZ (82 mg/kg i.p.). GL only antagonized the PTZ convulsions and lethality. The above results seem to demonstrate the importance of GABA-ergic and glycinergic receptors in the control of PTZ convulsions and they are supported by the recent data on the role of the inhibiting neuromediators, GABA and glycine, in the substantia nigra.