Lead-203 VMT-α-Neuroendocrine Tumor Scintigraphy: A Promising Theranostics Agent.

IF 0.4 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Indian Journal of Nuclear Medicine Pub Date : 2024-03-01 Epub Date: 2024-05-29 DOI:10.4103/ijnm.ijnm_2_23
Parul Thakral, Ishita Barat Sen, Subha Shankar Das, Michael K Schultz, Jyotsna Kumari, C B Virupakshappa, Dharmender Malik
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引用次数: 0

Abstract

Targeted alpha therapy (TAT) using lead-212 (Pb-212)-labeled peptides presents an attractive option for the treatment of metastatic neuroendocrine tumors (NETs). As Pb-203 presents an accurate diagnostic surrogate to Pb-212, imaging with Pb-203-labelled peptides can be an important prerequisite to assess the feasibility of TAT with Pb-212-labelled agents. Here, we present the imaging data of a patient with metastatic NET with Pb-203 VMT-α-NET, a somatostatin receptor targeting agent, and demonstrate the matching distribution of Pb-203 VMT-α-NET with Ga-68 DOTANOC.

铅-203 VMT-α-神经内分泌肿瘤闪烁成像:一种前景广阔的治疗药物。
使用铅-212(Pb-212)标记的肽进行靶向α治疗(TAT)是治疗转移性神经内分泌肿瘤(NET)的一个极具吸引力的选择。由于 Pb-203 是 Pb-212 的精确诊断替代物,因此用 Pb-203 标记肽进行成像是评估用 Pb-212 标记制剂进行 TAT 可行性的重要前提。在此,我们展示了一位转移性NET患者使用Pb-203 VMT-α-NET(一种体生长抑素受体靶向药物)的成像数据,并展示了Pb-203 VMT-α-NET与Ga-68 DOTANOC的匹配分布。
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来源期刊
Indian Journal of Nuclear Medicine
Indian Journal of Nuclear Medicine RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
0.70
自引率
0.00%
发文量
46
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