Defining Optimal Cobalamin Status for Neonates and Infants.

IF 1.8 4区医学 Q3 FOOD SCIENCE & TECHNOLOGY

Food and Nutrition Bulletin Pub Date : 2024-06-01 DOI:10.1177/03795721241227782

Anne-Lise Bjørke-Monsen

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引用次数: 0

Abstract

Background: An optimal cobalamin status is necessary for normal neurodevelopment.

Objective: To give a description of the epidemiology, pathophysiology and diagnostic challenges related to cobalamin insufficiency in neonates and infants in order to prevent its occurence.

Results: Inadequate cobalamin status is prevalent among neonates and young infants, due to a high prevalence of maternal cobalamin deficiency, exclusive breastfeeding for extended periods and late introduction of animal food. Cobalamin insufficiency is associated with delayed neurodevelopment and subtle clinical symptoms like feeding difficulties, regurgitations and constipation in young infants. Early diagnosis and treatment of impaired cobalamin status is important to prevent neurologic damage.

Conclusion: Clinical suspicion of cobalamin insufficiency in infants should infer immediate biochemical testing and a plasma total homocysteine > 5.0 µmol/L indicate cobalamin insufficiency in need of intramuscular treatment with hydroxycobalamin, followed by introduction of animal food after 4 months of age.

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确定新生儿和婴儿的最佳钴胺素状态。

背景最佳的钴胺素状态是正常神经发育的必要条件：描述新生儿和婴儿钴胺素缺乏症的流行病学、病理生理学和诊断难题，以预防其发生：钴胺素缺乏症在新生儿和婴幼儿中很普遍，这是因为母体钴胺素缺乏症发病率高、长期纯母乳喂养以及较晚才开始食用动物食品。钴胺素不足会导致神经发育迟缓，并使幼婴出现喂养困难、反胃和便秘等细微临床症状。早期诊断和治疗钴胺素缺乏症对预防神经系统损伤非常重要：结论：临床怀疑婴儿钴胺素缺乏应立即进行生化检测，血浆总同型半胱氨酸> 5.0 µmol/L表明钴胺素缺乏，需要肌肉注射羟钴胺治疗，然后在婴儿4个月大后添加动物性食物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food and Nutrition Bulletin 工程技术-食品科技

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

18-36 weeks

期刊介绍： The Food and Nutrition Bulletin (FNB,) is a peer-reviewed, academic journal published quarterly by the Nevin Scrimshaw International Nutrition Foundation. The Journal is one of the leading resources used by researchers, academics, nutrition policy makers and planners in over 125 countries to obtain the most current research and policy information related to nutrition in developing countries.