The role of the mediodorsal thalamus in chemosensory preference and consummatory behavior in rats.

IF 2.8 4区 心理学 Q1 BEHAVIORAL SCIENCES
Kelly E Gartner, Chad L Samuelsen
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引用次数: 0

Abstract

Experience plays a pivotal role in determining our food preferences. Consuming food generates odor-taste associations that shape our perceptual judgements of chemosensory stimuli, such as their intensity, familiarity, and pleasantness. The process of making consummatory choices relies on a network of brain regions to integrate and process chemosensory information. The mediodorsal thalamus is a higher-order thalamic nucleus involved in many experience-dependent chemosensory behaviors, including olfactory attention, odor discrimination, and the hedonic perception of flavors. Recent research has shown that neurons in the mediodorsal thalamus represent the sensory and affective properties of experienced odors, tastes, and odor-taste mixtures. However, its role in guiding consummatory choices remains unclear. To investigate the influence of the mediodorsal thalamus in the consummatory choice for experienced odors, tastes, and odor-taste mixtures, we pharmacologically inactivated the mediodorsal thalamus during 2-bottle brief-access tasks. We found that inactivation altered the preference for specific odor-taste mixtures, significantly reduced consumption of the preferred taste and increased within-trial sampling of both chemosensory stimulus options. Our results show that the mediodorsal thalamus plays a crucial role in consummatory decisions related to chemosensory preference and attention.

丘脑内侧在大鼠化感偏好和消耗行为中的作用
经验在决定我们对食物的偏好方面起着举足轻重的作用。食用食物会产生气味-味道联想,从而形成我们对化学感官刺激的知觉判断,如刺激的强度、熟悉度和愉悦度。做出消费选择的过程依赖于一个整合和处理化学感觉信息的脑区网络。丘脑内侧是一个高级丘脑核,参与许多依赖经验的化学感觉行为,包括嗅觉注意、气味辨别和对味道的享乐感知。最近的研究表明,丘脑内侧的神经元代表了经验气味、味道和气味-味道混合物的感觉和情感属性。然而,它在指导消费选择方面的作用仍不清楚。为了研究丘脑内侧在经验气味、味道和气味-味道混合物的消费性选择中的影响,我们在两瓶酒的短暂获取任务中对丘脑内侧进行了药理失活。我们发现,失活改变了对特定气味-味道混合物的偏好,显著减少了对首选味道的消耗,并增加了对两种化学感觉刺激选项的试验内取样。我们的研究结果表明,丘脑内侧在与化学感觉偏好和注意力相关的消耗性决策中起着至关重要的作用。
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来源期刊
Chemical Senses
Chemical Senses 医学-行为科学
CiteScore
8.60
自引率
2.90%
发文量
25
审稿时长
1 months
期刊介绍: Chemical Senses publishes original research and review papers on all aspects of chemoreception in both humans and animals. An important part of the journal''s coverage is devoted to techniques and the development and application of new methods for investigating chemoreception and chemosensory structures.
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