Dormancy, Quiescence, and Diapause: Savings Accounts for Life.

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Hatice Özge Özgüldez, Aydan Bulut-Karslioğlu
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引用次数: 0

Abstract

Life on Earth has been through numerous challenges over eons and, one way or another, has always triumphed. From mass extinctions to more daily plights to find food, unpredictability is everywhere. The adaptability of life-forms to ever-changing environments is the key that confers life's robustness. Adaptability has become synonymous with Darwinian evolution mediated by heritable genetic changes. The extreme gene-centric view, while being of central significance, at times has clouded our appreciation of the cell as a self-regulating entity informed of, and informing, the genetic data. An essential element that powers adaptability is the ability to regulate cell growth. In this review, we provide an extensive overview of growth regulation spanning species, tissues, and regulatory mechanisms. We aim to highlight the commonalities, as well as differences, of these phenomena and their molecular regulators. Finally, we curate open questions and areas for further exploration.

休眠、静止和暂停:生命储蓄账户
地球上的生命在漫长的岁月中经历了无数挑战,但总是以这样或那样的方式取得胜利。从大面积的生物灭绝到更多的日常觅食困境,不可预知性无处不在。生命形式对不断变化的环境的适应能力是赋予生命强大生命力的关键。适应性已成为以遗传基因变化为媒介的达尔文进化论的代名词。这种极端的以基因为中心的观点虽然具有核心意义,但有时却遮蔽了我们对细胞作为一个自我调节实体的认识,因为细胞是由基因数据提供信息的。增强适应能力的一个基本要素是调节细胞生长的能力。在这篇综述中,我们广泛概述了跨越物种、组织和调控机制的生长调控。我们旨在强调这些现象及其分子调节机制的共性和差异。最后,我们提出了有待进一步探讨的开放性问题和领域。
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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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