The Challenges of Lobular Carcinomas from a Surgeon’s Point of View

IF 2.9 3区医学 Q2 ONCOLOGY

Clinical breast cancer Pub Date : 2024-06-19 DOI:10.1016/j.clbc.2024.06.007

Margit L.H. Riis

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引用次数: 0

Abstract

Invasive lobular breast cancer (ILC) presents unique challenges and considerations in the realm of surgical management. Characterized by its distinct histological features, including the loss of E-cadherin expression and dys-cohesive growth pattern, ILC often poses diagnostic and therapeutic dilemmas for clinicians. This abstract explores the surgical landscape of ILC, focusing on its epidemiology, clinical presentation, diagnostic modalities, and surgical interventions. Emphasizing the importance of individualized treatment strategies, this narrative delves into the nuances of surgical decision-making, including the role of breast-conserving surgery versus mastectomy, axillary staging, and the significance of margin status. Additionally, advancements in surgical techniques, such as oncoplastic approaches and sentinel lymph node biopsy, are examined in the context of optimizing oncologic outcomes and preserving cosmesis. Through a comprehensive review of current literature and clinical guidelines, this overview aims to provide a nuanced understanding of the surgical considerations inherent to the management of invasive lobular breast cancer.

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从外科医生的角度看肺叶癌的挑战

浸润性小叶乳腺癌（ILC）给外科治疗带来了独特的挑战和考量。浸润性小叶乳腺癌具有独特的组织学特征，包括 E-cadherin 表达缺失和生长模式不粘连，常常给临床医生带来诊断和治疗上的难题。本摘要探讨了 ILC 的外科治疗情况，重点是其流行病学、临床表现、诊断方式和外科干预措施。本文强调了个体化治疗策略的重要性，并深入探讨了手术决策的细微差别，包括保乳手术与乳房切除术的作用、腋窝分期以及边缘状态的重要性。此外，还从优化肿瘤治疗效果和保护外观的角度，探讨了肿瘤整形方法和前哨淋巴结活检等手术技术的进步。通过对当前文献和临床指南的全面回顾，本综述旨在让读者对浸润性小叶乳腺癌的外科治疗注意事项有一个细致入微的了解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical breast cancer 医学-肿瘤学

CiteScore

5.40

自引率

3.20%

发文量

174

审稿时长

48 days

期刊介绍： Clinical Breast Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of breast cancer. Clinical Breast Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of breast cancer. The main emphasis is on recent scientific developments in all areas related to breast cancer. Specific areas of interest include clinical research reports from various therapeutic modalities, cancer genetics, drug sensitivity and resistance, novel imaging, tumor genomics, biomarkers, and chemoprevention strategies.