Oxidative stress modulating nanomaterials and their biochemical roles in nanomedicine

IF 8 2区 材料科学 Q1 CHEMISTRY, PHYSICAL
Kapil D. Patel, Zalike Keskin-Erdogan, Prasad Sawadkar, Nik Syahirah Aliaa Nik Sharifulden, Mark Robert Shannon, Madhumita Patel, Lady Barrios Silva, Rajkumar Patel, David Y. S. Chau, Jonathan C. Knowles, Adam W. Perriman and Hae-Won Kim
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Abstract

Many pathological conditions are predominantly associated with oxidative stress, arising from reactive oxygen species (ROS); therefore, the modulation of redox activities has been a key strategy to restore normal tissue functions. Current approaches involve establishing a favorable cellular redox environment through the administration of therapeutic drugs and redox-active nanomaterials (RANs). In particular, RANs not only provide a stable and reliable means of therapeutic delivery but also possess the capacity to finely tune various interconnected components, including radicals, enzymes, proteins, transcription factors, and metabolites. Here, we discuss the roles that engineered RANs play in a spectrum of pathological conditions, such as cancer, neurodegenerative diseases, infections, and inflammation. We visualize the dual functions of RANs as both generator and scavenger of ROS, emphasizing their profound impact on diverse cellular functions. The focus of this review is solely on inorganic redox-active nanomaterials (inorganic RANs). Additionally, we deliberate on the challenges associated with current RANs-based approaches and propose potential research directions for their future clinical translation.

Abstract Image

氧化应激调节纳米材料及其在纳米医学中的生化作用
许多病理状况主要与活性氧(ROS)引起的氧化应激有关;因此,调节氧化还原活动一直是恢复正常组织功能的关键策略。目前的方法包括通过施用治疗药物和氧化还原活性纳米材料(RANs)来建立有利的细胞氧化还原环境。特别是,氧化还原活性纳米材料不仅能提供稳定可靠的治疗给药方式,还能精细调节各种相互关联的成分,包括自由基、酶、蛋白质、转录因子和代谢物。在这里,我们将讨论工程 RANs 在癌症、神经退行性疾病、感染和炎症等一系列病理情况中发挥的作用。我们直观地展示了 RANs 作为 ROS 生成器和清除器的双重功能,强调了它们对各种细胞功能的深远影响。本综述的重点仅在于无机氧化还原活性纳米材料(无机 RANs)。此外,我们还探讨了当前基于 RANs 的方法所面临的挑战,并为其未来的临床转化提出了潜在的研究方向。
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来源期刊
Nanoscale Horizons
Nanoscale Horizons Materials Science-General Materials Science
CiteScore
16.30
自引率
1.00%
发文量
141
期刊介绍: Nanoscale Horizons stands out as a premier journal for publishing exceptionally high-quality and innovative nanoscience and nanotechnology. The emphasis lies on original research that introduces a new concept or a novel perspective (a conceptual advance), prioritizing this over reporting technological improvements. Nevertheless, outstanding articles showcasing truly groundbreaking developments, including record-breaking performance, may also find a place in the journal. Published work must be of substantial general interest to our broad and diverse readership across the nanoscience and nanotechnology community.
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