Okoh Adeyi Okoh, Clare L. Lawrence, Roger H. Bisby, Sarah L. Brennan, Robert B. Smith
{"title":"Towards structurally new cyanine dyes—investigating the photophysical and potential antifungal properties of linear substituted heptamethine dyes","authors":"Okoh Adeyi Okoh, Clare L. Lawrence, Roger H. Bisby, Sarah L. Brennan, Robert B. Smith","doi":"10.1111/cote.12780","DOIUrl":null,"url":null,"abstract":"The synthesis of a range of new linear substituted heptamethine dyes has been designed and described. The photophysical properties of all the dyes were investigated, with many exhibiting improved fluorescent quantum yields when compared with indocyanine green. Finally, growth inhibition studies were performed in the fission yeast <jats:italic>Saccharomyces pombe</jats:italic>, which suggests potential antifungals activity in the μM range.","PeriodicalId":10502,"journal":{"name":"Coloration Technology","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coloration Technology","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1111/cote.12780","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
The synthesis of a range of new linear substituted heptamethine dyes has been designed and described. The photophysical properties of all the dyes were investigated, with many exhibiting improved fluorescent quantum yields when compared with indocyanine green. Finally, growth inhibition studies were performed in the fission yeast Saccharomyces pombe, which suggests potential antifungals activity in the μM range.
期刊介绍:
The primary mission of Coloration Technology is to promote innovation and fundamental understanding in the science and technology of coloured materials by providing a medium for communication of peer-reviewed research papers of the highest quality. It is internationally recognised as a vehicle for the publication of theoretical and technological papers on the subjects allied to all aspects of coloration. Regular sections in the journal include reviews, original research and reports, feature articles, short communications and book reviews.