Casting a wider net: The clinical potential of EV transcriptomics in multi-analyte liquid biopsy

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-07-08 DOI:10.1016/j.ccell.2024.06.007

Yari Ciani, Caterina Nardella, Francesca Demichelis

引用次数: 0

Abstract

Cancer cells release cell-free DNA (cfDNA) and extracellular vesicles (EVs) into the bloodstream, allowing disease non-invasive monitoring. In this issue of Cancer Cell, Casanova-Salas et al. analyze cfDNA, EV-DNA, and EV-RNA in prostate cancer longitudinal cohorts treated with androgen receptor signaling inhibitors and taxanes, identifying signals reflecting tumor adaptation processes.

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撒下更大的网：EV转录组学在多分析物液体活检中的临床潜力

癌细胞会向血液中释放无细胞DNA（cfDNA）和细胞外囊泡（EVs），从而实现对疾病的无创监测。在本期《癌细胞》（Cancer Cell）杂志上，Casanova-Salas等人分析了接受雄激素受体信号抑制剂和紫杉类药物治疗的前列腺癌纵向队列中的cfDNA、EV-DNA和EV-RNA，确定了反映肿瘤适应过程的信号。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.