White matter and cortical gray matter microstructural abnormalities in new daily persistent headache: a NODDI study.

IF 7.3 1区医学 Q1 CLINICAL NEUROLOGY

Journal of Headache and Pain Pub Date : 2024-07-08 DOI:10.1186/s10194-024-01815-1

Zhilei Li, Yanliang Mei, Wei Wang, Lei Wang, Shouyi Wu, Kaibo Zhang, Dong Qiu, Zhonghua Xiong, Xiaoshuang Li, Ziyu Yuan, Peng Zhang, Mantian Zhang, Qiuling Tong, Zhenchang Zhang, Yonggang Wang

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引用次数: 0

Abstract

Background: New daily persistent headache (NDPH) is a rare primary headache with unclear pathogenesis. Neuroimaging studies of NDPH are limited, and controversy still exists. Diffusion tensor imaging (DTI) is commonly used to study the white matter. However, lacking specificity, the potential pathological mechanisms of white matter microstructural changes remain poorly understood. In addition, the intricacy of gray matter structures impedes the application of the DTI model. Here, we applied an advanced diffusion model of neurite orientation dispersion and density imaging (NODDI) to study the white matter and cortical gray matter microstructure in patients with NDPH.

Methods: This study assessed brain microstructure, including 27 patients with NDPH, and matched 28 healthy controls (HCs) by NODDI. The differences between the two groups were assessed by tract-based spatial statistics (TBSS) and surface-based analysis (SBA), focusing on the NODDI metrics (neurite density index (NDI), orientation dispersion index (ODI), and isotropic volume fraction (ISOVF)). Furthermore, we performed Pearson's correlation analysis between the NODDI indicators and clinical characteristics.

Results: Compared to HCs, patients with NDPH had a reduction of density and complexity in several fiber tracts. For robust results, the fiber tracts were defined as comprising more than 100 voxels, including bilateral inferior fronto-occipital fasciculus (IFOF), left superior longitudinal fasciculus (SLF) and inferior longitudinal fasciculus (ILF), as well as right corticospinal tract (CST). Moreover, the reduction of neurite density was uncovered in the left superior and middle frontal cortex, left precentral cortex, and right lateral orbitofrontal cortex and insula. There was no correlation between the NODDI metrics of these brain regions and clinical variables or scales of relevance after the Bonferroni correction.

Conclusions: Our research indicated that neurite loss was detected in both white matter and cortical gray matter of patients with NDPH.

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新发每日持续性头痛的白质和皮质灰质微结构异常：NODDI 研究。

背景：新的每日持续性头痛（NDPH）是一种罕见的原发性头痛，发病机制尚不清楚。对 NDPH 的神经影像学研究十分有限，而且仍然存在争议。弥散张量成像（DTI）通常用于研究白质。然而，由于缺乏特异性，人们对白质微结构变化的潜在病理机制仍然知之甚少。此外，灰质结构的复杂性也阻碍了 DTI 模型的应用。在此，我们应用先进的神经元取向弥散和密度成像（NODDI）扩散模型来研究 NDPH 患者的白质和皮质灰质微观结构：本研究通过 NODDI 评估了 27 名 NDPH 患者和 28 名健康对照组（HCs）的大脑微观结构。通过基于道的空间统计（TBSS）和基于表面的分析（SBA）评估了两组之间的差异，重点是NODDI指标（神经元密度指数（NDI）、方向分散指数（ODI）和各向同性体积分数（ISOVF））。此外，我们还对NODDI指标和临床特征进行了皮尔逊相关分析：结果：与 HC 相比，NDPH 患者的多个纤维束的密度和复杂性都有所降低。为了得到可靠的结果，纤维束被定义为包含100个以上体素，包括双侧下额枕束（IFOF）、左上纵束（SLF）和下纵束（ILF）以及右皮质脊髓束（CST）。此外，左侧额叶上部和中部皮层、左侧前额叶皮层、右侧眶额叶皮层和岛叶的神经元密度也有所降低。经 Bonferroni 校正后，这些脑区的 NODDI 指标与临床变量或相关量表之间不存在相关性：我们的研究表明，在NDPH患者的白质和皮质灰质中都发现了神经元丢失。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Headache and Pain 医学-临床神经学

CiteScore

11.80

自引率

13.50%

发文量

143

审稿时长

6-12 weeks

期刊介绍： The Journal of Headache and Pain, a peer-reviewed open-access journal published under the BMC brand, a part of Springer Nature, is dedicated to researchers engaged in all facets of headache and related pain syndromes. It encompasses epidemiology, public health, basic science, translational medicine, clinical trials, and real-world data. With a multidisciplinary approach, The Journal of Headache and Pain addresses headache medicine and related pain syndromes across all medical disciplines. It particularly encourages submissions in clinical, translational, and basic science fields, focusing on pain management, genetics, neurology, and internal medicine. The journal publishes research articles, reviews, letters to the Editor, as well as consensus articles and guidelines, aimed at promoting best practices in managing patients with headaches and related pain.