Mitochondrial Structure, Dynamics, and Physiology: Light Microscopy to Disentangle the Network.

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
Juan C Landoni, Tatjana Kleele, Julius Winter, Willi Stepp, Suliana Manley
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引用次数: 0

Abstract

Mitochondria serve as energetic and signaling hubs of the cell: This function results from the complex interplay between their structure, function, dynamics, interactions, and molecular organization. The ability to observe and quantify these properties often represents the puzzle piece critical for deciphering the mechanisms behind mitochondrial function and dysfunction. Fluorescence microscopy addresses this critical need and has become increasingly powerful with the advent of superresolution methods and context-sensitive fluorescent probes. In this review, we delve into advanced light microscopy methods and analyses for studying mitochondrial ultrastructure, dynamics, and physiology, and highlight notable discoveries they enabled.

线粒体结构、动力学和生理学:用光学显微镜解构网络。
线粒体是细胞的能量和信号枢纽:这种功能是线粒体的结构、功能、动力学、相互作用和分子组织之间复杂相互作用的结果。观察和量化这些特性的能力往往是破译线粒体功能和功能障碍背后机制的关键谜题。荧光显微镜满足了这一关键需求,随着超分辨率方法和上下文敏感荧光探针的出现,荧光显微镜变得越来越强大。在这篇综述中,我们将深入探讨用于研究线粒体超微结构、动力学和生理学的先进光学显微镜方法和分析,并重点介绍它们带来的重大发现。
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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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