Platelet indices in children with type 1 diabetes mellitus: a simple glucoregulation monitoring tool.

African health sciences Pub Date : 2023-12-01 DOI:10.4314/ahs.v23i4.35

Dejan Dobrijević, Jelena Antić, Goran Rakić, Ljiljana Andrijević

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Abstract

Introduction: Long-term hyperglycemia can lead to changes in the function and morphology of platelets.

Objective: This study aimed to test the potential glucoregulation monitoring properties of platelet indices, mean platelet volume (MPV) and platelet distribution width (PDW), in children with type 1 diabetes mellitus (T1DM).

Methods: The study included 453 patients below the age of 18 with T1DM treated at the Institute for Child and Youth Health Care of Vojvodina. Children were divided into two groups, according to their glucoregulation quality, i.e., glycated hemoglobin (HbA1c) levels. Descriptive and inferential statistical analyses were performed.

Results: MPV and PDW were found to be important in predicting poor glucoregulation, both in independent and conjoint analysis. Proposed cut-off values for MPV and PDW in the glucose control monitoring of children with T1DM were 7.6 fL and 14.4%, respectively.

Conclusion: Our study showed that MPV and PDW have monitoring properties in terms of glucose control in children with T1DM. Additionally, our study emphasizes the importance of selecting the most convenient control group in order to avoid misleading conclusions.

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1 型糖尿病患儿的血小板指数：一种简单的葡萄糖调节监测工具。

简介：长期高血糖会导致血小板的功能和形态发生变化：长期高血糖会导致血小板的功能和形态发生变化：本研究旨在检测1型糖尿病（T1DM）儿童血小板指数、血小板平均体积（MPV）和血小板分布宽度（PDW）的潜在糖代谢监测特性：研究对象包括在伏伊伏丁那儿童和青少年保健研究所接受治疗的 453 名 18 岁以下 T1DM 患者。根据糖调节质量，即糖化血红蛋白（HbA1c）水平，儿童被分为两组。研究人员进行了描述性和推论性统计分析：结果：在独立分析和联合分析中，MPV 和 PDW 被认为是预测糖代谢不良的重要指标。在 T1DM 儿童血糖控制监测中，建议的 MPV 和 PDW 临界值分别为 7.6 fL 和 14.4%：我们的研究表明，MPV 和 PDW 具有监测 T1DM 儿童血糖控制的特性。此外，我们的研究还强调了选择最方便的对照组以避免得出误导性结论的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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African health sciences

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