Combination of Nicotinamide and Agastache rugosa Extract: A Potent Strategy for Protecting Hs68 Cells from UVB-Induced Photoaging.

IF 1.6 Q3 FOOD SCIENCE & TECHNOLOGY
Seungjoo Baik, Huijin Heo, Seonghwa Hong, Heon Sang Jeong, Junsoo Lee, Hana Lee
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Abstract

This study investigated the protective effects of nicotinamide (NAM) and Agastache rugosa extract (AR) against ultraviolet B (UVB)-induced photoaging in Hs68 cells. The results demonstrated that NAM and AR, alone or in combination, exhibited concentration-dependent protective effects against UVB radiation. The highest synergistic effect was observed at a NAM:AR ratio of 6:4. This combination exhibited a synergistic protective effect against UVB-induced photoaging. The sample concentration required for 80% cell survival was 9.70 μM and 131.16 ppm for NAM and AR, respectively. However, when combined, they exhibited strong synergistic effects with concentrations as low as 0.11 μM and 17.50 ppm. Moreover, 5.26 μM of NAM and 1,082.13 ppm of AR were required to inhibit 30% of reactive oxygen species, but the combination treatment required 0.62 μM and 95.49 ppm, respectively. This combination significantly reduced the production of matrix metalloproteinase and increased collagen production. These findings highlight the potential of combining NAM and AR as functional cosmetic materials to protect against UVB-induced photoaging. The synergistic effects observed in this study provide valuable information for developing novel strategies for cosmetic combinations that target UVB-mediated skin damage.

烟酰胺与姬松茸提取物的结合:保护 Hs68 细胞免受紫外线诱导的光老化的有效策略
本研究探讨了烟酰胺(NAM)和姬松茸提取物(AR)对紫外线 B(UVB)诱导的 Hs68 细胞光老化的保护作用。结果表明,NAM 和 AR 单独或混合使用,对 UVB 辐射具有浓度依赖性的保护作用。当 NAM 与 AR 的比例为 6:4 时,协同效应最高。这种组合对紫外线诱导的光老化具有协同保护作用。细胞存活率达到 80% 所需的样本浓度分别为 9.70 μM 和 131.16 ppm。然而,当两者结合使用时,它们表现出了很强的协同效应,浓度分别低至 0.11 μM 和 17.50 ppm。此外,需要 5.26 μM 的 NAM 和 1,082.13 ppm 的 AR 才能抑制 30% 的活性氧,而联合处理则分别需要 0.62 μM 和 95.49 ppm。这种组合能明显减少基质金属蛋白酶的产生,并增加胶原蛋白的产生。这些发现凸显了将 NAM 和 AR 结合起来作为功能性化妆品材料以防止紫外线引起的光老化的潜力。本研究中观察到的协同效应为开发针对紫外线介导的皮肤损伤的新型化妆品组合策略提供了宝贵的信息。
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来源期刊
Preventive Nutrition and Food Science
Preventive Nutrition and Food Science Agricultural and Biological Sciences-Food Science
CiteScore
3.40
自引率
0.00%
发文量
35
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