Impact of Photobiomodulation on IL1β and TGFβ-1 concentrations in patients with aphthous stomatitis.

IF 2.1 4区医学 Q3 ENGINEERING, BIOMEDICAL

Lasers in Medical Science Pub Date : 2024-07-08 DOI:10.1007/s10103-024-04130-y

Dalia Saleem Kareem, Layla M H Al-Ameri, Ammar Saleh Alalawi

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Abstract

Laser therapy has shown effectiveness in promoting wound healing by influencing various physiological factors such as blood flow, cytokines, histamine, nerve signals, lymphocyte function, tissue oxygenation, and cell growth. This study aims to evaluate the therapeutic efficacy of Photobiomodulation (PBM) treatment, by using diode laser, in modifying the levels of interleukin-1 beta (IL1β) and transforming growth factor beta-1 (TGFβ-1) in patients diagnosed with aphthous stomatitis. A before-after interventional design was conducted over 10 months with 20 subjects. Data on demographic details and serum concentrations of IL1β and TGFβ-1 were collected pre-treatment and on Days 3 and 7 post-treatments. The intervention involved a single session of four 30-second applications of a QuickLase dual-wavelength laser operating at 980 nm. Results show significant reductions in IL1β and TGFβ-1 levels after 7 days of treatment, indicating a time-dependent effect of PBM therapy on these inflammatory markers. The findings suggest that PBM therapy holds promise as an intervention for reducing inflammation associated with aphthous stomatitis.

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光生物调节对口腔炎患者体内 IL1β 和 TGFβ-1 浓度的影响

激光疗法通过影响各种生理因素，如血流、细胞因子、组胺、神经信号、淋巴细胞功能、组织氧合和细胞生长，在促进伤口愈合方面显示出其有效性。本研究旨在评估使用二极管激光进行光生物调制（PBM）治疗对改变口腔炎患者白细胞介素-1β（IL1β）和转化生长因子β-1（TGFβ-1）水平的疗效。该研究对 20 名受试者进行了为期 10 个月的前后干预设计。在治疗前、治疗后第 3 天和第 7 天收集了有关人口统计学细节、IL1β 和 TGFβ-1 血清浓度的数据。干预措施包括使用波长为 980 纳米的 QuickLase 双波长激光器进行四次单次治疗，每次 30 秒。结果显示，治疗 7 天后，IL1β 和 TGFβ-1 水平明显下降，这表明 PBM疗法对这些炎症标志物的影响具有时间依赖性。研究结果表明，PBM疗法有望成为减少与口腔炎相关的炎症的干预措施。

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来源期刊

Lasers in Medical Science 医学-工程：生物医学

CiteScore

4.50

自引率

4.80%

发文量

192

审稿时长

3-8 weeks

期刊介绍： Lasers in Medical Science (LIMS) has established itself as the leading international journal in the rapidly expanding field of medical and dental applications of lasers and light. It provides a forum for the publication of papers on the technical, experimental, and clinical aspects of the use of medical lasers, including lasers in surgery, endoscopy, angioplasty, hyperthermia of tumors, and photodynamic therapy. In addition to medical laser applications, LIMS presents high-quality manuscripts on a wide range of dental topics, including aesthetic dentistry, endodontics, orthodontics, and prosthodontics. The journal publishes articles on the medical and dental applications of novel laser technologies, light delivery systems, sensors to monitor laser effects, basic laser-tissue interactions, and the modeling of laser-tissue interactions. Beyond laser applications, LIMS features articles relating to the use of non-laser light-tissue interactions.