Protocol and rationale of the Australian multicentre registry for serial cardiac computed tomography angiography (ARISTOCRAT): a prospective observational study of the natural history of pericoronary adipose tissue attenuation and radiomics.

IF 2.1 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular diagnosis and therapy Pub Date : 2024-06-30 Epub Date: 2024-06-27 DOI:10.21037/cdt-23-392

Kevin Cheng, Andrew Lin, Peter J Psaltis, Adil Rajwani, Angus Baumann, Nicholas Brett, Nadarajah Kangaharan, James Otton, Stephen J Nicholls, Damini Dey, Dennis T L Wong

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引用次数: 0

Abstract

Background: Vascular inflammation plays a crucial role in the development of atherosclerosis and atherosclerotic plaque rupture resulting in acute coronary syndrome (ACS). Pericoronary adipose tissue (PCAT) attenuation quantified from routine coronary computed tomography angiography (CCTA) has emerged as a promising non-invasive imaging biomarker of coronary inflammation. However, a detailed understanding of the natural history of PCAT attenuation is required before it can be used as a surrogate endpoint in trials of novel therapies targeting coronary inflammation. This article aims to explore the natural history of PCAT attenuation and its association with changes in plaque characteristics.

Methods: The Australian natuRal hISTOry of periCoronary adipose tissue attenuation, RAdiomics and plaque by computed Tomographic angiography (ARISTOCRAT) registry is a multi-centre observational registry enrolling patients undergoing clinically indicated serial CCTA in 9 centres across Australia. CCTA scan parameters will be matched across serial scans. Quantitative analysis of plaque and PCAT will be performed using semiautomated software.

Discussion: The primary endpoint is to explore temporal changes in patient-level and lesion-level PCAT attenuation by CCTA and their associations with changes in plaque characteristics. Secondary endpoints include evaluating: (I) impact of statin therapy on PCAT attenuation and plaque characteristics; and (II) changes in PCAT attenuation and plaque characteristics in specific subgroups according to sex and risk factors. ARISTOCRAT will further our understanding of the natural history of PCAT attenuation and its association with changes in plaque characteristics.

Trial registration: This study has been prospectively registered with the Australia and New Zealand Clinical Trials Registry (ACTRN12621001018808).

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澳大利亚连续心脏计算机断层扫描血管造影多中心登记（ARISTOCRAT）的协议和原理：冠状动脉周围脂肪组织衰减和放射组学自然史的前瞻性观察研究。

背景：血管炎症在动脉粥样硬化和动脉粥样硬化斑块破裂导致急性冠状动脉综合征（ACS）的发生发展中起着至关重要的作用。通过常规冠状动脉计算机断层扫描血管造影术（CCTA）量化的冠状动脉周围脂肪组织（PCAT）衰减已成为冠状动脉炎症的一种有前途的非侵入性成像生物标志物。然而，在针对冠状动脉炎症的新型疗法试验中将其用作替代终点之前，需要详细了解 PCAT 衰减的自然史。本文旨在探讨PCAT衰减的自然史及其与斑块特征变化的关联：澳大利亚冠状动脉周围脂肪组织衰减、Radiomics 和斑块计算机断层扫描（ARISTOCRAT）自然史登记是一项多中心观察登记，在澳大利亚的 9 个中心登记了接受有临床指征的连续 CCTA 检查的患者。CCTA 扫描参数将在连续扫描中进行匹配。将使用半自动软件对斑块和PCAT进行定量分析：讨论：主要终点是通过 CCTA 探索患者水平和病变水平 PCAT 衰减的时间变化及其与斑块特征变化的关系。次要终点包括评估：(I) 他汀类药物治疗对 PCAT 衰减和斑块特征的影响；(II) PCAT 衰减和斑块特征在特定亚组中根据性别和风险因素的变化。ARISTOCRAT将使我们进一步了解PCAT衰减的自然史及其与斑块特征变化的关系：本研究已在澳大利亚和新西兰临床试验注册中心（Australia and New Zealand Clinical Trials Registry）进行了前瞻性注册（ACTRN12621001018808）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular diagnosis and therapy Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

4.20%

发文量

期刊介绍： The journal ''Cardiovascular Diagnosis and Therapy'' (Print ISSN: 2223-3652; Online ISSN: 2223-3660) accepts basic and clinical science submissions related to Cardiovascular Medicine and Surgery. The mission of the journal is the rapid exchange of scientific information between clinicians and scientists worldwide. To reach this goal, the journal will focus on novel media, using a web-based, digital format in addition to traditional print-version. This includes on-line submission, review, publication, and distribution. The digital format will also allow submission of extensive supporting visual material, both images and video. The website www.thecdt.org will serve as the central hub and also allow posting of comments and on-line discussion. The web-site of the journal will be linked to a number of international web-sites (e.g. www.dxy.cn), which will significantly expand the distribution of its contents.