The Roles of Exosomes in Regulating Hair Follicle Growth

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-05 DOI:10.2147/ccid.s465963

Ming Cheng, Cong Ma, Hong-Duo Chen, Yan Wu, Xue-Gang Xu

引用次数: 0

Abstract

Abstract: Alopecia is considered a widespread yet troubling health issue, with limited treatment options. As membranous structures derived from cells carrying proteins, nucleic acids and lipids, exosomes functionally medicate intercellular communication and alter the responses of recipient cells, resulting in disease restraint or promotion. Exosomes have broad prospects in diagnosis and treatment of diseases. Studies using animal models and at the cellular level have clearly shown that exosomes from several types of cells, including dermal papilla cells and mesenchymal stem cells, have a notable capacity to promote hair growth, suggesting that exosomes may provide a new option to treat alopecia. Here, we present a thorough review of the most recent progress in the application of exosomes to hair growth.

Keywords: exosome, hair follicle, alopecia

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外泌体在调节毛囊生长中的作用

摘要：脱发被认为是一个普遍而又令人担忧的健康问题，但治疗方法却很有限。外泌体是一种来自细胞的膜结构，携带蛋白质、核酸和脂质，具有细胞间通信和改变受体细胞反应的功能，从而抑制或促进疾病的发生。外泌体在诊断和治疗疾病方面具有广阔的前景。利用动物模型和细胞水平进行的研究清楚地表明，来自真皮乳头细胞和间充质干细胞等几类细胞的外泌体具有显著的促进毛发生长的能力，这表明外泌体可能为治疗脱发提供一种新的选择。在此，我们对外泌体应用于毛发生长的最新进展进行了全面综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.