Assessment of environmental and biological stress using mitochondria-targeted red-emitting and near-infrared fluorescent probes for biothiol analysis: a review

IF 15 2区环境科学与生态学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Environmental Chemistry Letters Pub Date : 2024-07-04 DOI:10.1007/s10311-024-01761-z

Wen-Yu Lu, Hui-Jing Li, Yan-Chao Wu

引用次数: 0

Abstract

Levels of biological thiols, or “biothiols,” in mitochondria can be used to assess environmental and biological oxidative stress, which can cause health issues such as malignant tumors and neurological diseases. Here, we review fluorescent probes for detecting biothiols, targeting mitochondria, and emitting red and near-infrared light, with focus on nitrogen cation and oxonium ion units as mitochondrial biomarkers. Red-emitting and near-infrared fluorescent probes for detecting biothiols are classified according to the way they target mitochondria. We present the structure, fluorescence behavior, and biological imaging of the probes.

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利用线粒体靶向发射红光和近红外荧光探针进行生物硫醇分析，评估环境和生物压力：综述

线粒体中的生物硫醇或 "生物硫醇 "水平可用于评估环境和生物氧化应激，氧化应激可导致恶性肿瘤和神经系统疾病等健康问题。在此，我们回顾了用于检测生物硫醇、靶向线粒体、发射红光和近红外光的荧光探针，重点介绍了作为线粒体生物标记物的氮阳离子和氧离子单元。用于检测生物硫醇的发射红光和近红外荧光探针可根据其靶向线粒体的方式进行分类。我们介绍了探针的结构、荧光行为和生物成像。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Chemistry Letters 环境科学-工程：环境

CiteScore

32.00

自引率

7.00%

发文量

175

审稿时长

2 months

期刊介绍： Environmental Chemistry Letters explores the intersections of geology, chemistry, physics, and biology. Published articles are of paramount importance to the examination of both natural and engineered environments. The journal features original and review articles of exceptional significance, encompassing topics such as the characterization of natural and impacted environments, the behavior, prevention, treatment, and control of mineral, organic, and radioactive pollutants. It also delves into interfacial studies involving diverse media like soil, sediment, water, air, organisms, and food. Additionally, the journal covers green chemistry, environmentally friendly synthetic pathways, alternative fuels, ecotoxicology, risk assessment, environmental processes and modeling, environmental technologies, remediation and control, and environmental analytical chemistry using biomolecular tools and tracers.