Viral hepatitis moderates the impact of TGFB1 on neurocognitive impairment.

The Kaohsiung journal of medical sciences Pub Date : 2024-09-01 Epub Date: 2024-07-06 DOI:10.1002/kjm2.12872
Wei-Chia Tsao, Rwei-Ling Yu, Chi-Ting Li, Wei-Fang Tsai, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Chun-Hsiang Tan
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Abstract

Recent studies have identified a correlation between chronic viral hepatitis and cognitive impairment, yet the underlying mechanisms remain unclear. This study investigated the influence of TGFB1 genetic polymorphisms on cognitive function in individuals with and without hepatitis infections, hypothesizing that these polymorphisms and the viral hepatitis-induced inflammatory environment interact to affect cognitive abilities. Participants (173 with viral hepatitis and 258 healthy controls) were recruited. Genotyping of TGFB1 SNPs was performed using the C2-58 Axiom Genome-Wide TWB 2.0 Array Plate. Cognitive function was assessed using the MMSE and MoCA tests. Our results showed that healthy individuals carrying the C allele of rs2241715 displayed better performance in sentence writing (p = 0.020) and language tasks (p = 0.022). Notably, viral hepatitis was found to moderate the impact of the rs2241715 genotype on language function (p = 0.002). Similarly, those carrying the T allele of rs10417924 demonstrated superior orientation to time (p = 0.002), with viral hepatitis modifying the influence of the SNP on this particular cognitive function (p = 0.010). Our findings underscore the significant role of TGFβ1 in cognitive function and the moderating impact of viral hepatitis on TGFB1 SNP effects. These findings illuminate the potential of TGFB1 as a therapeutic target for cognitive impairment induced by viral hepatitis, thus broadening our understanding of TGFβ1 functionality in the pathogenesis of neurodegeneration.

病毒性肝炎可调节 TGFB1 对神经认知障碍的影响。
最近的研究发现慢性病毒性肝炎与认知障碍之间存在相关性,但其潜在机制仍不清楚。本研究调查了 TGFB1 基因多态性对肝炎感染者和非肝炎感染者认知功能的影响,假设这些多态性和病毒性肝炎诱发的炎症环境相互作用,从而影响认知能力。研究招募了参与者(173 名病毒性肝炎患者和 258 名健康对照者)。使用 C2-58 Axiom 全基因组 TWB 2.0 阵列板对 TGFB1 SNPs 进行基因分型。认知功能采用 MMSE 和 MoCA 测试进行评估。结果显示,携带 rs2241715 的 C 等位基因的健康人在句子写作(p = 0.020)和语言任务(p = 0.022)中表现更好。值得注意的是,病毒性肝炎可减缓 rs2241715 基因型对语言功能的影响(p = 0.002)。同样,携带 rs10417924 的 T 等位基因的人表现出更强的时间定向能力(p = 0.002),病毒性肝炎可调节 SNP 对这一特定认知功能的影响(p = 0.010)。我们的研究结果强调了 TGFβ1 在认知功能中的重要作用,以及病毒性肝炎对 TGFB1 SNP 影响的调节作用。这些发现揭示了 TGFB1 作为病毒性肝炎引起的认知功能障碍的治疗靶点的潜力,从而拓宽了我们对 TGFβ1 在神经退行性病变发病机制中的功能的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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