Can intravenous lorazepam prevent postictal generalized EEG suppression? A case report

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2024-01-01 DOI:10.1016/j.cnp.2024.06.002

Zack Ramilevich, Katherine Zarroli

引用次数: 0

Abstract

Background

Postictal generalized electrographic suppression (PGES) may be considered an electrophysiological marker associated with an increased risk of sudden unexplained death in epilepsy (SUDEP).

Case Presentation

A case study is presented whereby a young man with focal to bilateral tonic-clonic seizures exhibited PGES after two spontaneously-aborted seizures; yet, after a third benzodiazepine-aborted seizure, PGES was absent.

Conclusion

This suggests that acutely administered benzodiazepines may offer direct anti-suppressive effects to prevent PGES, potentially reducing SUDEP risk.

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静脉注射劳拉西泮能预防发作后全身脑电图抑制吗？病例报告

背景癫痫发作后全身电图抑制（PGES）可能被认为是与癫痫不明原因猝死（SUDEP）风险增加相关的电生理标志。病例介绍本研究中的一个病例显示，一名患有局灶性至双侧强直阵挛发作的年轻男子在两次自发中止的癫痫发作后出现了 PGES；然而，在第三次苯二氮卓中止的癫痫发作后，PGES 消失了。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.