Central dentinogenic ghost cell tumor of the maxilla: a case report with new imaging findings and review of the literature.

IF 1.6 3区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Oral Radiology Pub Date : 2024-10-01 Epub Date: 2024-07-05 DOI:10.1007/s11282-024-00764-4
Suzuka Yoshida, Yohei Takeshita, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Kyoichi Obata, Kiyofumi Takabatake, Saori Yoshida, Junichi Asaumi
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Abstract

A dentinogenic ghost cell tumor (DGCT) is a rare benign odontogenic tumor that commonly shows characteristics of solid proliferation and has a relatively high risk of recurrence after surgical treatment. We herein report a case of a central DGCT that occurred in the maxilla and resulted in bone expansion. This study highlights new imaging findings (particularly magnetic resonance imaging) along with histopathological observations. In addition, we conducted a review of the existing literature on this rare tumor. A 37-year-old man developed swelling around the right cheek. A benign odontogenic tumor such as ameloblastoma was suspected based on the imaging examination findings (including bone expansion and the internal characteristics of the tumor) on panoramic imaging, computed tomography, and magnetic resonance imaging. The lesion was surgically excised from the right maxilla. Postoperative histopathological examination led to a definitive diagnosis of central DGCT. The tumor comprised epithelial neoplastic islands, resembling ameloblastoma, inside tight fibroconnective tissue; masses of ghost cells and formation of dentin were also observed. We had suspected that the minute high-density region around the molars on the imaging examinations represented alveolar bone change; however, it represented dentin formation. This led to difficulty diagnosing the lesion. Although DGCT may present characteristic findings on imaging examinations, its occurrence is infrequent, and in some cases, the findings may include the presence or absence of an impacted tooth without obvious calcification. The present case suggests that we should consider the possibility of an odontogenic tumor with calcification when high-density structures are observed inside the lesion.

Abstract Image

上颌骨中心性牙本质鬼细胞瘤:病例报告、新的影像学发现和文献综述。
牙本质鬼细胞瘤(DGCT)是一种罕见的良性牙源性肿瘤,通常具有实体增殖的特征,手术治疗后复发的风险相对较高。我们在此报告一例发生在上颌骨并导致骨膨胀的中心性 DGCT。本研究重点介绍了新的影像学发现(尤其是磁共振成像)和组织病理学观察结果。此外,我们还回顾了有关这种罕见肿瘤的现有文献。一名 37 岁的男子右脸颊周围出现肿胀。根据全景成像、计算机断层扫描和磁共振成像的成像检查结果(包括骨膨胀和肿瘤内部特征),怀疑是牙源性良性肿瘤,如釉母细胞瘤。手术从右侧上颌骨切除了病灶。术后组织病理学检查明确诊断为中心性 DGCT。肿瘤由上皮性肿瘤岛组成,类似于釉母细胞瘤,位于紧密的纤维结缔组织内;还观察到大量鬼细胞和牙本质的形成。我们曾怀疑影像学检查中臼齿周围的微小高密度区代表牙槽骨变化,但它却代表牙本质形成。这给病变的诊断带来了困难。虽然 DGCT 在影像学检查中可能呈现出特征性的结果,但其发生率并不高,在某些病例中,其结果可能包括存在或不存在没有明显钙化的撞击牙。本病例提示我们,如果在病变内部观察到高密度结构,则应考虑牙源性肿瘤伴钙化的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Oral Radiology
Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
4.20
自引率
13.60%
发文量
87
审稿时长
>12 weeks
期刊介绍: As the official English-language journal of the Japanese Society for Oral and Maxillofacial Radiology and the Asian Academy of Oral and Maxillofacial Radiology, Oral Radiology is intended to be a forum for international collaboration in head and neck diagnostic imaging and all related fields. Oral Radiology features cutting-edge research papers, review articles, case reports, and technical notes from both the clinical and experimental fields. As membership in the Society is not a prerequisite, contributions are welcome from researchers and clinicians worldwide.
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