Chemotherapy-induced oral mucositis: hierarchical analysis of recurrence factors.

IF 2.3 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
T S de Macêdo, M C F de Melo, A K A Ferreira, E L M S da Silva-Selva, G P Godoy, A de F Caldas Júnior
{"title":"Chemotherapy-induced oral mucositis: hierarchical analysis of recurrence factors.","authors":"T S de Macêdo, M C F de Melo, A K A Ferreira, E L M S da Silva-Selva, G P Godoy, A de F Caldas Júnior","doi":"10.1007/s40368-024-00919-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze, through a hierarchical model, the risk factors associated with the recurrence of chemo-induced oral mucositis (OM) in children and adolescents.</p><p><strong>Methods: </strong>A retrospective cohort with 31 individuals of both sexes, aged 1-18 years, who were undergoing chemotherapy, and presented OM lesions was conducted. Data collection included analysis of medical records, interviews, and intraoral examination. Information regarding patients' socioeconomic and demographic profile, underlying disease, antineoplastic regimen, hematological condition, and oral health status were collected. To assess the association of independent variables with the outcome, the Chi-square, Fisher's Exact, and Mann-Whitney tests were used, in addition to a binary logistic regression model, with a maximum error of 5% and a 95% confidence interval.</p><p><strong>Results: </strong>Significant associations were observed between the history of OM and the diagnosis of the child/adolescent, neutrophil count, previous cancer treatments and the chemotherapy scheme in use (p < 0.05). Binary logistic regression revealed a 13.69 higher risk of developing OM recurrence in individuals who received high-dose methotrexate (MTX) therapy.</p><p><strong>Conclusion: </strong>Socioeconomic and demographic factors did not influence OM recurrence. However, clinical variables, such as neutropenia, diagnosis of leukemia, and high-dose MTX protocols increase the chance of OM new cases.</p>","PeriodicalId":47603,"journal":{"name":"European Archives of Paediatric Dentistry","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Archives of Paediatric Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40368-024-00919-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/5 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: This study aimed to analyze, through a hierarchical model, the risk factors associated with the recurrence of chemo-induced oral mucositis (OM) in children and adolescents.

Methods: A retrospective cohort with 31 individuals of both sexes, aged 1-18 years, who were undergoing chemotherapy, and presented OM lesions was conducted. Data collection included analysis of medical records, interviews, and intraoral examination. Information regarding patients' socioeconomic and demographic profile, underlying disease, antineoplastic regimen, hematological condition, and oral health status were collected. To assess the association of independent variables with the outcome, the Chi-square, Fisher's Exact, and Mann-Whitney tests were used, in addition to a binary logistic regression model, with a maximum error of 5% and a 95% confidence interval.

Results: Significant associations were observed between the history of OM and the diagnosis of the child/adolescent, neutrophil count, previous cancer treatments and the chemotherapy scheme in use (p < 0.05). Binary logistic regression revealed a 13.69 higher risk of developing OM recurrence in individuals who received high-dose methotrexate (MTX) therapy.

Conclusion: Socioeconomic and demographic factors did not influence OM recurrence. However, clinical variables, such as neutropenia, diagnosis of leukemia, and high-dose MTX protocols increase the chance of OM new cases.

化疗引起的口腔黏膜炎:复发因素的层次分析。
目的:本研究旨在通过层次模型分析与儿童和青少年化疗引起的口腔黏膜炎(OM)复发相关的风险因素:方法:对 31 名正在接受化疗并出现口腔黏膜炎病变的 1-18 岁男女患者进行了回顾性队列研究。数据收集包括病历分析、访谈和口腔内检查。收集的信息涉及患者的社会经济和人口概况、基础疾病、抗肿瘤疗法、血液状况和口腔健康状况。为了评估自变量与结果之间的关系,除了使用二元逻辑回归模型(最大误差为 5%,置信区间为 95%)外,还使用了卡方检验(Chi-square)、费雪精确检验(Fisher's Exact)和曼惠特尼检验(Mann-Whitney):观察发现,OM 病史与儿童/青少年的诊断、中性粒细胞计数、既往癌症治疗和正在使用的化疗方案之间存在显著关联(p 结论:OM 病史与儿童/青少年的诊断、中性粒细胞计数、既往癌症治疗和正在使用的化疗方案之间存在显著关联:社会经济和人口学因素不会影响 OM 复发。然而,中性粒细胞减少症、白血病诊断和大剂量 MTX 方案等临床变量会增加 OM 新病例的发生几率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
European Archives of Paediatric Dentistry
European Archives of Paediatric Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
4.40
自引率
9.10%
发文量
81
期刊介绍: The aim and scope of European Archives of Paediatric Dentistry (EAPD) is to promote research in all aspects of dentistry for children, including interceptive orthodontics and studies on children and young adults with special needs. The EAPD focuses on the publication and critical evaluation of clinical and basic science research related to children. The EAPD will consider clinical case series reports, followed by the relevant literature review, only where there are new and important findings of interest to Paediatric Dentistry and where details of techniques or treatment carried out and the success of such approaches are given.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信