Risk of stroke development following retinal vein occlusion: A systematic review and meta-analysis

IF 5.1 2区 医学 Q1 OPHTHALMOLOGY
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Abstract

Retinal vein occlusion (RVO) and cerebrovascular disease share common risk factors and may be independently associated; however, the strength and nature of this association remain unclear. We conducted a systematic review and meta-analysis, informed by studies from PubMed, Scopus, EMBASE, Web of Science, and Google Scholar until January 6, 2024, aimed to clarify this relationship. Eligible studies included cohorts observing stroke incidence in RVO patients for over a year. Pooled effect estimates were calculated using random-effects models, with subgroup analyses evaluating associations between RVO types (central and branch) and stroke subtypes (ischemic and hemorrhagic). Ten cohort studies with a total of 428,650 participants (86,299 RVO patients) were included. Compared to controls, RVO patients exhibited a significantly increased risk of stroke (pooled risk ratio [RR]=1.38, 95 % confidence interval (95 %CI)=1.34–1.41). Subgroup analyses indicated elevated risk for both ischemic (RR=1.37, 95 %CI=1.32–1.42) and hemorrhagic (RR=1.55, 95 %CI=1.08–2.22) strokes in RVO patients. Additionally, both central (RR=1.50, 95 %CI=1.27–1.78) and branch (RR=1.41, 95 %CI=1.32–1.50) RVO were associated with stroke risk. Sensitivity analyses confirmed consistent results across various criteria, and funnel plots indicated no publication bias. RVO significantly increases the risk of both ischemic and hemorrhagic stroke, regardless of RVO type, suggesting a strong independent association between these conditions.

视网膜静脉闭塞后发生中风的风险:系统回顾和荟萃分析。
视网膜静脉闭塞(RVO)和脑血管疾病(CVD)有共同的风险因素,而且可能是独立相关的;然而,这种关联的强度和性质仍不清楚。我们进行了一项系统性综述和荟萃分析,参考了截至 2024 年 1 月 6 日来自 PubMed、Scopus、EMBASE、Web of Science 和 Google Scholar 的研究,旨在澄清这种关系。符合条件的研究包括观察 RVO 患者中风发生率一年以上的队列。采用随机效应模型计算汇总效应估计值,并通过亚组分析评估 RVO 类型(中央型和分支型)与中风亚型(缺血性和出血性)之间的关系。十项队列研究共纳入 428650 名参与者(86299 名 RVO 患者)。与对照组相比,RVO 患者发生中风的风险明显增加(汇总风险比 [RR]=1.38, 95% 置信区间 (95%CI)=1.34-1.41 )。亚组分析表明,RVO 患者缺血性中风(RR=1.37,95%CI=1.32-1.42)和出血性中风(RR=1.55,95%CI=1.08-2.22)的风险均升高。此外,中心型(RR=1.50,95%CI=1.27-1.78)和分支型(RR=1.41,95%CI=1.32-1.50)RVO 均与中风风险相关。敏感性分析证实各种标准的结果一致,漏斗图显示无发表偏倚。无论 RVO 类型如何,RVO 都会明显增加缺血性和出血性中风的风险,这表明这些疾病之间存在很强的独立关联。
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来源期刊
Survey of ophthalmology
Survey of ophthalmology 医学-眼科学
CiteScore
10.30
自引率
2.00%
发文量
138
审稿时长
14.8 weeks
期刊介绍: Survey of Ophthalmology is a clinically oriented review journal designed to keep ophthalmologists up to date. Comprehensive major review articles, written by experts and stringently refereed, integrate the literature on subjects selected for their clinical importance. Survey also includes feature articles, section reviews, book reviews, and abstracts.
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