Defining myeloid-derived suppressor cells

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2024-07-05 DOI:10.1038/s41577-024-01062-0

Leila Akkari, Ido Amit, Vincenzo Bronte, Zvi G. Fridlender, Dmitry I. Gabrilovich, Florent Ginhoux, Catherine C. Hedrick, Suzanne Ostrand-Rosenberg

引用次数: 0

Abstract

Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

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定义髓源性抑制细胞。

髓源性抑制细胞（MDSCs）是中性粒细胞和单核细胞系的细胞，具有强大的免疫抑制活性。对小鼠和人类的大量研究发现，MDSCs 在抑制抗肿瘤反应和决定癌症免疫疗法疗效方面发挥着重要作用。然而，关于多发性骨髓造血干细胞的身份、本体和功能仍存在许多争议，必须解决这些问题才能发挥其治疗潜力。在本视点中，《自然-免疫学评论》邀请了该领域的八位专家分享他们对MDSC研究中的关键问题和挑战的看法。在本视点中，《自然-免疫学评论》邀请八位该领域的专家分享他们对MDSC研究中的关键问题和挑战的看法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.