Comparing the clinical characteristics and outcomes of septic shock children with and without malignancies: a retrospective cohort study

IF 2.8 4区医学 Q1 PEDIATRICS

Jornal de pediatria Pub Date : 2024-07-03 DOI:10.1016/j.jped.2024.06.003

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引用次数: 0

Abstract

Objective

There is an amelioration in mortality rates of septic shock patients with malignancies over time, but it remains uncertain in children. Therefore, the authors endeavored to compare the clinical characteristics, treatment needs, and outcomes of septic shock children with or without malignancies.

Methods

The authors retrospectively analyzed the data of children admitted to the PICU due to septic shock from January 2015 to December 2022 in a tertiary pediatric hospital. The main outcome was in-hospital mortality.

Results

A total of 508 patients were enrolled. The proportion of Gram-negative bacteria and fungal infections in children with malignancies was significantly higher than those without malignancies. Septic shock children with malignancies had a longer length of stay (LOS) in the hospital (21 vs. 11 days, p<0.001). However, there were no statistically significant differences in the LOS of PICU (5 vs. 5 days, p = 0.591), in-hospital mortality (43.0 % vs. 49.4 %, p = 0.276), and 28-day mortality (49.2 % vs. 44.7 %, p = 0.452). The 28-day survival analysis (p = 0.314) also showed no significant differences.

Conclusion

Although there are significant differences in the bacterial spectrum of infections, the septic shock children with or without malignancies showed a similar mortality rate. The septic shock children with malignancies had longer LOS of the hospital.

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比较患有和未患有恶性肿瘤的脓毒性休克患儿的临床特征和预后：一项回顾性队列研究。

目的：随着时间的推移，患有恶性肿瘤的脓毒性休克患者的死亡率有所下降，但儿童患者的死亡率仍不确定。因此，作者试图比较有无恶性肿瘤的脓毒性休克患儿的临床特征、治疗需求和预后：作者回顾性分析了一家三级儿科医院2015年1月至2022年12月因脓毒性休克入住PICU的患儿数据。主要结果是院内死亡率：结果：共有508名患者入院。恶性肿瘤患儿的革兰氏阴性菌和真菌感染比例明显高于非恶性肿瘤患儿。患有恶性肿瘤的脓毒症休克患儿的住院时间（LOS）更长（21 天对 11 天，p）：虽然感染的细菌谱存在明显差异，但患有或未患有恶性肿瘤的脓毒性休克患儿的死亡率相似。患有恶性肿瘤的脓毒性休克患儿的住院时间更长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jornal de pediatria 医学-小儿科

CiteScore

5.60

自引率

3.00%

发文量

审稿时长

43 days

期刊介绍： Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.