Association between anemia and vitamin D deficiency in German seniors : A retrospective data analysis.

IF 1.1 4区 医学 Q4 GERIATRICS & GERONTOLOGY
Dorothee Magdalena Schuchart, Ingrid Becker, Birgit Harbeck, Gabriele Röhrig
{"title":"Association between anemia and vitamin D deficiency in German seniors : A retrospective data analysis.","authors":"Dorothee Magdalena Schuchart, Ingrid Becker, Birgit Harbeck, Gabriele Röhrig","doi":"10.1007/s00391-024-02322-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Anemia and deficiency of vitamin D (VDD) are frequently seen in seniors and an association is suspected. Approximately one third of the German population is affected by VDD, with a rising prevalence among seniors.</p><p><strong>Aim: </strong>To analyze the association between anemia and VDD among German seniors aged ≥ 60 years.</p><p><strong>Methods: </strong>Retrospective cross-sectional data analysis (n = 4008) in a nationwide working laboratory medical center (January-December 2019). Study parameters included amongst others: hemoglobin (Hb), calcifediol (25D) and calcitriol (1.25D), glomerular filtration rate (GFR) to assess the kidney disease outcomes quality initiative (KDOQI) state. The inclusion criteria were age ≥ 60 years, normal C‑reactive protein (CRP) and leucocyte levels.</p><p><strong>Results: </strong>The 25D was estimated in 4008 patients and 1.25D only in 411 patients. Mean age 75 years (± 8.61 years; 60-99 years) with 30.6% males; mean GFR 62 ml/min/1.73 m<sup>3</sup> (± 22.74); 20% of patients were anemic, 35% were deficient for 25D (< 50 nmol/l), with men > women (p = 0.014). Linear regression analysis revealed a significant effect of 25D values < 30 nmol/l on hemoglobin in males of KDOQI I-III and females of KDOQI I-IV (R2 = 0.052; p = 0.005; and R2 = 0.124; p < 0.001, respectively). For 1.25D a weak but significant effect on hemoglobin independent of KDOQI was only seen in women (R2 = 0.200; p = 0.005).</p><p><strong>Conclusion: </strong>In this cohort deficiency of 25D and 1.25D was significantly associated with hemoglobin independent of renal function only in women but not in men.</p>","PeriodicalId":49345,"journal":{"name":"Zeitschrift Fur Gerontologie Und Geriatrie","volume":" ","pages":"563-568"},"PeriodicalIF":1.1000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift Fur Gerontologie Und Geriatrie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00391-024-02322-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/5 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Anemia and deficiency of vitamin D (VDD) are frequently seen in seniors and an association is suspected. Approximately one third of the German population is affected by VDD, with a rising prevalence among seniors.

Aim: To analyze the association between anemia and VDD among German seniors aged ≥ 60 years.

Methods: Retrospective cross-sectional data analysis (n = 4008) in a nationwide working laboratory medical center (January-December 2019). Study parameters included amongst others: hemoglobin (Hb), calcifediol (25D) and calcitriol (1.25D), glomerular filtration rate (GFR) to assess the kidney disease outcomes quality initiative (KDOQI) state. The inclusion criteria were age ≥ 60 years, normal C‑reactive protein (CRP) and leucocyte levels.

Results: The 25D was estimated in 4008 patients and 1.25D only in 411 patients. Mean age 75 years (± 8.61 years; 60-99 years) with 30.6% males; mean GFR 62 ml/min/1.73 m3 (± 22.74); 20% of patients were anemic, 35% were deficient for 25D (< 50 nmol/l), with men > women (p = 0.014). Linear regression analysis revealed a significant effect of 25D values < 30 nmol/l on hemoglobin in males of KDOQI I-III and females of KDOQI I-IV (R2 = 0.052; p = 0.005; and R2 = 0.124; p < 0.001, respectively). For 1.25D a weak but significant effect on hemoglobin independent of KDOQI was only seen in women (R2 = 0.200; p = 0.005).

Conclusion: In this cohort deficiency of 25D and 1.25D was significantly associated with hemoglobin independent of renal function only in women but not in men.

德国老年人贫血与维生素 D 缺乏之间的关系 :回顾性数据分析
背景:贫血和维生素 D 缺乏症(VDD)在老年人中经常出现,而且怀疑两者之间存在关联。德国约有三分之一的人口受到维生素 D 缺乏的影响,而老年人中的发病率正在上升:在一家全国性工作实验室医疗中心进行回顾性横断面数据分析(n = 4008)(2019 年 1 月至 12 月)。研究参数主要包括:血红蛋白(Hb)、降钙素三醇(25D)和降钙素三醇(1.25D)、肾小球滤过率(GFR),以评估肾脏疾病结果质量倡议(KDOQI)状态。纳入标准为年龄≥60岁、C反应蛋白(CRP)和白细胞水平正常:结果:对 4008 名患者的 25D 进行了估计,仅对 411 名患者的 1.25D 进行了估计。平均年龄 75 岁(± 8.61 岁;60-99 岁),男性占 30.6%;平均 GFR 62 ml/min/1.73 m3(± 22.74);20% 的患者贫血,35% 的患者缺乏 25D(女性)(p = 0.014)。线性回归分析表明,25D 值有显著影响:在该队列中,25D 和 1.25D 的缺乏与血红蛋白显著相关,与肾功能无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
2.00
自引率
16.70%
发文量
126
审稿时长
6-12 weeks
期刊介绍: The fact that more and more people are becoming older and are having a significant influence on our society is due to intensive geriatric research and geriatric medicine in the past and present. The Zeitschrift für Gerontologie und Geriatrie has contributed to this area for many years by informing a broad spectrum of interested readers about various developments in gerontology research. Special issues focus on all questions concerning gerontology, biology and basic research of aging, geriatric research, psychology and sociology as well as practical aspects of geriatric care. Target group: Geriatricians, social gerontologists, geriatric psychologists, geriatric psychiatrists, nurses/caregivers, nurse researchers, biogerontologists in geriatric wards/clinics, gerontological institutes, and institutions of teaching and further or continuing education.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信