An emerging role for the gut microbiome in tauopathy.

IF 5.6 2区 医学 Q1 CLINICAL NEUROLOGY
Neurotherapeutics Pub Date : 2024-10-01 Epub Date: 2024-07-03 DOI:10.1016/j.neurot.2024.e00423
Yiyang Zhu, Wade K Self, David M Holtzman
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引用次数: 0

Abstract

Tauopathies constitute a group of neurodegenerative diseases characterized by abnormal aggregation of the protein tau, progressive neuronal and synaptic loss, and eventual cognitive and motor impairment. In this review, we will highlight the latest efforts investigating the intricate interplay between the gut microbiome and tauopathies. We discuss the physiological interactions between the microbiome and the brain as well as clinical and experimental evidence that suggests that the presence of tauopathy alters the composition of gut microbiota. We explore both animal and human studies that define causative relationships between the gut microbiome and tauopathy by directly manipulating or transferring gut microbiota. This review highlights future directions into identifying and mechanistically elucidating microbial species causally linked to tauopathies, with an ultimate goal of devising therapeutic targets towards the gut microbiome to treat tauopathies.

肠道微生物组在牛磺酸病中的新作用。
tau病是一组神经退行性疾病,其特征是蛋白质tau的异常聚集、神经元和突触的进行性丧失以及最终的认知和运动障碍。在本综述中,我们将重点介绍研究肠道微生物组与 tau 病之间错综复杂的相互作用的最新进展。我们将讨论微生物群与大脑之间的生理相互作用,以及表明陶陶病的存在会改变肠道微生物群组成的临床和实验证据。我们探讨了通过直接操纵或转移肠道微生物群来确定肠道微生物群与牛脑病之间因果关系的动物和人体研究。本综述强调了确定和从机理上阐明与陶陶病有因果关系的微生物物种的未来方向,其最终目标是设计出针对肠道微生物组的治疗靶点来治疗陶陶病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neurotherapeutics
Neurotherapeutics 医学-神经科学
CiteScore
11.00
自引率
3.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: Neurotherapeutics® is the journal of the American Society for Experimental Neurotherapeutics (ASENT). Each issue provides critical reviews of an important topic relating to the treatment of neurological disorders written by international authorities. The Journal also publishes original research articles in translational neuroscience including descriptions of cutting edge therapies that cross disciplinary lines and represent important contributions to neurotherapeutics for medical practitioners and other researchers in the field. Neurotherapeutics ® delivers a multidisciplinary perspective on the frontiers of translational neuroscience, provides perspectives on current research and practice, and covers social and ethical as well as scientific issues.
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