Recent progress for chiral stationary phases based on chiral porous materials in high-performance liquid chromatography and gas chromatography separation

IF 2.8 3区工程技术 Q2 CHEMISTRY, ANALYTICAL

Journal of separation science Pub Date : 2024-07-05 DOI:10.1002/jssc.202400073

Zhen Wang, Wei Wang, Ai-Qin Luo, Li-Ming Yuan

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Abstract

Chirality is a fundamental property of nature. Separation and analysis of racemates are of great importance in the fields of medicine and the production of chiral biopharmaceutical intermediates. Chiral chromatography has the characteristics of a wide separation range, fast separation speed, and high efficiency. The development and preparation of novel chiral stationary phases with good chiral recognition and separation capacity is the core and key of chiral chromatographic separation and analysis. In this work, the representative research progress of novel chiral porous crystal materials including chiral covalent organic frameworks, chiral porous organic cages, chiral metal-organic frameworks, and chiral metal-organic cages used as chiral stationary phases of capillary gas chromatography and high-performance liquid chromatography over the last 4 years is reviewed in detail. The chiral recognition and separation properties of the representative studies in this review are also introduced and discussed.

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基于手性多孔材料的手性固定相在高效液相色谱和气相色谱分离领域的最新进展。

手性是自然界的基本属性。外消旋体的分离和分析在医药和手性生物制药中间体生产领域具有重要意义。手性色谱具有分离范围广、分离速度快、效率高等特点。开发和制备具有良好手性识别和分离能力的新型手性固定相是手性色谱分离和分析的核心和关键。本文详细综述了近 4 年来新型手性多孔晶体材料的代表性研究进展，包括手性共价有机框架、手性多孔有机笼、手性金属有机框架和手性金属有机笼，这些材料被用作毛细管气相色谱和高效液相色谱的手性固定相。此外，还介绍和讨论了本综述中代表性研究的手性识别和分离特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of separation science 化学-分析化学

CiteScore

6.30

自引率

16.10%

发文量

408

审稿时长

1.8 months

期刊介绍： The Journal of Separation Science (JSS) is the most comprehensive source in separation science, since it covers all areas of chromatographic and electrophoretic separation methods in theory and practice, both in the analytical and in the preparative mode, solid phase extraction, sample preparation, and related techniques. Manuscripts on methodological or instrumental developments, including detection aspects, in particular mass spectrometry, as well as on innovative applications will also be published. Manuscripts on hyphenation, automation, and miniaturization are particularly welcome. Pre- and post-separation facets of a total analysis may be covered as well as the underlying logic of the development or application of a method.